New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis
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Advances in targeting signal transduction pathwaysLifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycinXenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil: a new family of gerosuppressant agentsN-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.BMAL1-dependent regulation of the mTOR signaling pathway delays agingGenetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysisPhysiological frailty index (PFI): quantitative in-life estimate of individual biological age in miceLatest progress in tyrosine kinase inhibitorsFrom rapalogs to anti-aging formula.Dietary energy balance modulates ovarian cancer progression and metastasis.Adenosine triphosphate-competitive mTOR inhibitors: a new class of immunosuppressive agents that inhibit allograft rejectionTOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Selective anti-cancer agents as anti-aging drugsLongevity, aging and rapamycin.Rapamycin-induced metabolic defects are reversible in both lean and obese micep70 S6 kinase drives ovarian cancer metastasis through multicellular spheroid-peritoneum interaction and P-cadherin/b1 integrin signaling activation.p53 status as effect modifier of the association between pre-treatment fasting glucose and breast cancer outcomes in non diabetic, HER2 positive patients treated with trastuzumab.Gerosuppression in confluent cells.Genetic prevention of lymphoma in p53 knockout mice allows the early development of p53-related sarcomasTumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction.p53 and rapamycin are additive.Geroconversion: irreversible step to cellular senescenceComparison of rapamycin schedules in mice on high-fat diet.Koschei the immortal and anti-aging drugsDual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence.Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet.mTORC1 and p53: clash of the gods?Recent discoveries in the cycling, growing and aging of the p53 fieldMechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumorsRecent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.Adaptations to chronic rapamycin in mice.Rapamycin, Autophagy, and Alzheimer's DiseaseRapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.One-carbon metabolism: an aging-cancer crossroad for the gerosuppressant metforminRapamycin, anti-aging, and avoiding the fate of Tithonus
P2860
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P2860
New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
@zh-hant
name
New nanoformulation of rapamyc ...... ice by delaying carcinogenesis
@ast
New nanoformulation of rapamyc ...... ice by delaying carcinogenesis
@en
type
label
New nanoformulation of rapamyc ...... ice by delaying carcinogenesis
@ast
New nanoformulation of rapamyc ...... ice by delaying carcinogenesis
@en
prefLabel
New nanoformulation of rapamyc ...... ice by delaying carcinogenesis
@ast
New nanoformulation of rapamyc ...... ice by delaying carcinogenesis
@en
P2093
P2860
P356
P1433
P1476
New nanoformulation of rapamyc ...... ice by delaying carcinogenesis
@en
P2093
Alexander Polinsky
Andrei V Gudkov
Ilia Toshkov
Karen K Kuropatwinski
Maria Comas
Marina P Antoch
Olga B Chernova
P2860
P304
P356
10.18632/AGING.100496
P577
2012-10-01T00:00:00Z