Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. - Wikidata - awgldk - TriplyDB

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

http://www.wikidata.org/entity/Q36456030

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Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97)Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells The orphan nuclear receptor SHP utilizes conserved LXXLL-related motifs for interactions with ligand-activated estrogen receptors Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene The antiestrogen ICI 182,780 decreases the expression of estrogen receptor-alpha but has no effect on estrogen receptor-beta and androgen receptor in rat efferent ductules ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus Recognition and accommodation at the androgen receptor coactivator binding interface Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer.Estrogen receptor transcription and transactivation: Basic aspects of estrogen action.Problems for risk assessment of endocrine-active estrogenic compounds Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor.Structural insights into corepressor recognition by antagonist-bound estrogen receptors SKF-82958 is a subtype-selective estrogen receptor-alpha (ERalpha ) agonist that induces functional interactions between ERalpha and AP-1 Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions Extracellular signal-regulated kinase 7, a regulator of hormone-dependent estrogen receptor destruction.Truncated estrogen receptor product-1 suppresses estrogen receptor transactivation by dimerization with estrogen receptors alpha and beta.Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.The ligand-mediated nuclear mobility and interaction with estrogen-responsive elements of estrogen receptors are subtype specific.Dissection of the LXXLL nuclear receptor-coactivator interaction motif using combinatorial peptide libraries: discovery of peptide antagonists of estrogen receptors alpha and beta.Sex hormones: a role in the control of multiple sclerosis?Short peptides as biosensor transducers.A novel pesticide-induced conformational state of the oestrogen receptor ligand-binding domain, detected by conformation-specific peptide binding.The use of phage display technique for the isolation of androgen receptor interacting peptides with (F/W)XXL(F/W) and FXXLY new signature motifs.Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors.Hormone replacement therapy and fractures in older adults.Convergent evolution with combinatorial peptides.Minimal activators that bind to the KIX domain of p300/CBP identified by phage display screening.Differential biochemical and cellular actions of Premarin estrogens: distinct pharmacology of bazedoxifene-conjugated estrogens combination Estrogen receptor and the SERM concept.Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)Molecular and cellular mechanisms of estrogen action on the skeleton.The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes Delineation of a unique protein-protein interaction site on the surface of the estrogen receptor.Regulation of cholangiocyte proliferation.Noncanonical mechanisms to regulate nuclear receptor signaling.The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.Selective estrogen receptor modulators: tissue selectivity and differential uterine effects.

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P2860

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.

http://www.wikidata.org/entity/Q36456030

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Proceedings of the National Academy of Sciences of the United States of America

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Estrogen receptor (ER) modulat ...... hanges in ER alpha and ER beta

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C Y Chang

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D J Christensen

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D M Fowlkes

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D P McDonnell

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E B Gottlin

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H Grøn

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K M Padilla

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L A Paige

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L M Ballas

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P2860

Sequence and expression of human estrogen receptor complementary DNA

ER beta: identification and characterization of a novel human estrogen receptor

Cloning of a novel receptor expressed in rat prostate and ovary

Molecular basis of agonism and antagonism in the oestrogen receptor

The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

Sequence and characterization of a coactivator for the steroid hormone receptor superfamily

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

Basic guide to the mechanisms of antiestrogen action

Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer

Molecular determinants of tissue selectivity in estrogen receptor modulators.

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10.1073/PNAS.96.7.3999

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7

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96

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Paul T Hamilton

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13194354

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22409

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