Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter.
about
The binding sites for cocaine and dopamine in the dopamine transporter overlapComparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognitionStructural analysis of the extracellular entrance to the serotonin transporter permeation pathway.Conformational flexibility of transmembrane helix VII of the human serotonin transporter impacts ion dependence and transport.The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter.Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporterHelix XI contributes to the entrance of the serotonin transporter permeation pathway.1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.
P2860
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P2860
Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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name
Engineered zinc-binding sites ...... e human serotonin transporter.
@ast
Engineered zinc-binding sites ...... e human serotonin transporter.
@en
type
label
Engineered zinc-binding sites ...... e human serotonin transporter.
@ast
Engineered zinc-binding sites ...... e human serotonin transporter.
@en
prefLabel
Engineered zinc-binding sites ...... e human serotonin transporter.
@ast
Engineered zinc-binding sites ...... e human serotonin transporter.
@en
P2093
P2860
P356
P1433
P1476
Engineered zinc-binding sites ...... e human serotonin transporter.
@en
P2093
David E Nichols
Eric L Barker
Kellie J White
Philip D Kiser
P2860
P304
P356
10.1110/PS.062386106
P577
2006-10-01T00:00:00Z