Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design - Wikidata - awgldk - TriplyDB

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

http://www.wikidata.org/entity/Q36458325

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Toward high-resolution homology modeling of antibody Fv regions and application to antibody-antigen docking Design of protein-ligand binding based on the molecular-mechanics energy model The development of immunoconjugates for targeted cancer therapy Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding Affinities Molecular basis for passive immunotherapy of Alzheimer's disease Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering Advances in Antibody Design Direct prediction of profiles of sequences compatible with a protein structure by neural networks with fragment-based local and energy-based nonlocal profiles Computational tools for epitope vaccine design and evaluation Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions.Antibody H3 Structure Prediction.Affinity maturation of antibodies assisted by in silico modeling.Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC.Computational design of antibody-affinity improvement beyond in vivo maturation The protein-protein interface evolution acts in a similar way to antibody affinity maturation.OptCDR: a general computational method for the design of antibody complementarity determining regions for targeted epitope binding.Specific increase in potency via structure-based design of a TCR.Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method.MAPs: a database of modular antibody parts for predicting tertiary structures and designing affinity matured antibodies Applying physics-based scoring to calculate free energies of binding for single amino acid mutations in protein-protein complexes Random mutagenesis of BoNT/E Hc nanobody to construct a secondary phage-display library.OptMAVEn--a new framework for the de novo design of antibody variable region models targeting specific antigen epitopes.Antibody engineering for increased potency, breadth and half-life.Protein side chain conformation predictions with an MMGBSA energy function.Computer-aided antibody design.Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.Novel method for probing the specificity binding profile of ligands: applications to HIV protease.Progress in computational protein design.A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency.RosettaAntibody: antibody variable region homology modeling server.Energy functions in de novo protein design: current challenges and future prospects.Engineering the variable region of therapeutic IgG antibodies.Molecular engineering of antibodies for therapeutic and diagnostic purposes.Elucidation of potential sites for antibody engineering by fluctuation editing.Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction.Blind prediction performance of RosettaAntibody 3.0: grafting, relaxation, kinematic loop modeling, and full CDR optimization.AB-Bind: Antibody binding mutational database for computational affinity predictions.

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Affinity enhancement of an in vivo matured therapeutic antibody using structure-based computational design

http://www.wikidata.org/entity/Q36458325

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Protein Science

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Alexey Lugovskoy

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Bethany Friedman

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Christopher Fitch

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Herman Van Vlijmen

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John Eldredge

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Karl J M Hanf

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Mia Rushe

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P2860

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

Native protein sequences are close to optimal for their structures

Continuous cultures of fused cells secreting antibody of predefined specificity

Improved methods for building protein models in electron density maps and the location of errors in these models

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Contribution of intra- and intermolecular hydrogen bonds to the conformational stability of human lysozyme(,)

Design, activity, and structure of a highly specific artificial endonuclease

Crystal structure of the alpha1beta1 integrin I domain in complex with an antibody Fab fragment

X-ray snapshots of the maturation of an antibody response to a protein antigen

Repacking the Core of T4 lysozyme by automated design

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949-960

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10.1110/PS.052030506

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15

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