Development of α-helical calpain probes by mimicking a natural protein-protein interaction. - Wikidata - awgldk - TriplyDB

Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

http://www.wikidata.org/entity/Q36469004

about

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides Constraining cyclic peptides to mimic protein structure motifs.Comparative α-helicity of cyclic pentapeptides in water.Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.Helix Nucleation by the Smallest Known α-Helix in Water.Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target.Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers.Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides.Tightening up the structure, lighting up the pathway: Application of molecular constraints and light to manipulate protein folding, self-assembly and function.Enzyme-catalyzed macrocyclization of long unprotected peptides.Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions.Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation Conformational Restriction of Peptides Using Dithiol Bis-Alkylation Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling.Design of Potent and Proteolytically Stable Oxyntomodulin Analogs.A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling.Infrared and Fluorescence Assessment of Protein Dynamics: From Folding to Function.Assessment of local friction in protein folding dynamics using a helix cross-linker.How quickly can a β-hairpin fold from its transition state?Thioamide-based fluorescent protease sensors Converting disulfide bridges in native peptides to stable methylene thioacetals.An updated patent review of calpain inhibitors (2012 - 2014).Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Chemical Protein Modification through Cysteine.Review stapling peptides using cysteine crosslinking.The Cysteine S-Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences.Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.Calpain research for drug discovery: challenges and potential.Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.Intramolecular Hydrogen Bonding Involving Organic Fluorine: NMR Investigations Corroborated by DFT-Based Theoretical Calculations.α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.Receptor-templated stapling of intrinsically disordered peptide ligands.Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake.Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)-H activation.New peptide architectures through C-H activation stapling between tryptophan-phenylalanine/tyrosine residues Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.Double quick, double click reversible peptide "stapling".

P2860

Q27703615-B88AD6B1-81BD-4F27-9993-B3F821D8739B Q30367509-CEE21A70-2F7D-4EC8-802A-60EB947136CC Q30820760-955D8806-1228-4ADE-9A79-C021CA5E5360 Q30855871-E3B540D2-E0AE-464B-9FF0-37BFB949396F Q31102104-C0A4C59E-780C-47C9-904F-19C8BF0B476C Q31156352-995D9E80-5CDA-43C7-9880-20B9AF41CA12 Q33827087-249E0B98-6E62-4A50-9FDF-BBD1A68FB374 Q34245561-0F81F478-A725-480E-8F9A-504B85250569 Q35059832-BEBB61CC-BA53-4B23-8583-48668BD4D9AF Q35111788-175F8EAA-BA15-43A2-B4B4-770E2D9E59C0 Q35213008-E860381E-977B-4312-8C96-887146E20320 Q35532355-AE451EB4-7B32-452D-B7CA-46A5122E24D0 Q35781290-B9F2A7A2-54A4-4636-AD96-EB63343371E5 Q35950537-7EBD4A19-A571-4E29-9BFF-881AA8A025D7 Q36120663-65D4F1B7-B2E7-4D78-AC1B-36E16DEF47D9 Q36775960-EADF9E1E-3FDE-43BE-9D4D-A384772AB33A Q36884113-C6379DD0-8EE8-4FE1-9E99-4B12D1137565 Q36911032-6FE69C7D-7692-4B7D-9306-F1BC0D65917A Q37013963-04B0F7AA-643C-4A4D-A7D1-C9B0F2A97E3C Q37524802-D927E553-34AA-403B-B5AA-6011CE474C3E Q37671331-DDC6E86F-C049-4FBF-BAEC-09EB7112C674 Q37701012-75E8A389-02D6-42C1-9416-F1816754AD83 Q37707861-10C60717-F2F6-4229-A029-E229EABD5906 Q38268518-24FBA617-663B-4FD5-862C-ADFDCDE748F7 Q38539666-D5A7AA8E-D4FE-46BC-9BFB-28B10465CCEE Q38704033-489C5819-C301-4CD0-A022-F0BD7C396508 Q38834108-CA9EABF2-B6D1-4D97-8ACD-C718F0B26DDF Q38931075-AD91FA6B-2169-4F55-84C4-0B6B014B9A64 Q38944129-CC363CFD-0A82-4F91-9D5E-815CA28B60C9 Q39004902-9723C063-7EEE-4F97-B8C1-A5F7D2E1F67A Q39159976-6FE5A6E5-28FC-44DA-8770-9F7AD69D9179 Q39168113-E2D76D3A-13DE-4D26-8006-8278065B6EF6 Q40596592-DF22A505-93F9-45D7-A6B0-F841DC84CCE5 Q41250916-A90972A4-4AEE-42E6-B904-333D775FAC48 Q41253572-D4BC3C1F-C07E-4682-9D36-87EB388F116B Q41357964-969A147C-9C3D-47FA-914A-DE5C34FFC179 Q41528002-2D979265-04B0-461E-B40B-D3C2F972CC47 Q42067091-62819E1D-AE0E-4E9B-A6EA-CE0577609C5E Q42365672-D0C66EC2-1187-45EE-BE20-35DD7C2D1DED Q42365829-831CAA02-2A42-47F3-BA4E-8AA08881AB1A

P2860

Development of α-helical calpain probes by mimicking a natural protein-protein interaction.

http://www.wikidata.org/entity/Q36469004

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

2012年學術文章

@zh

2012年學術文章

@zh-hant

name

Development of α-helical calpa ...... l protein-protein interaction.

@ast

Development of α-helical calpa ...... l protein-protein interaction.

@en

type

label

Development of α-helical calpa ...... l protein-protein interaction.

@ast

Development of α-helical calpa ...... l protein-protein interaction.

@en

prefLabel

Development of α-helical calpa ...... l protein-protein interaction.

@ast

Development of α-helical calpa ...... l protein-protein interaction.

@en

P1433

Q36469004-0CFF6F11-3143-451F-8BAF-8B1065128365

P1476

Q36469004-AAF13CE0-2F5B-477E-83C7-F0300BF95D13

P2093

Q36469004-1EFA780D-D5ED-4043-8FD0-F374F180859D

Q36469004-2178F570-CB2E-48EE-B554-E95207443AA3

Q36469004-3F243249-7C20-4DAF-A17A-085354DEE6BC

Q36469004-612F8256-5765-412F-B625-AA76AEBBF54D

Q36469004-69260391-DAD7-45F8-B9E2-009DBECAE387

Q36469004-72ABF6D2-CF6B-4C18-BD9B-8B447F0B64BA

Q36469004-CA557F28-2873-4AFF-8C58-7DC859A83DC1

Q36469004-E1426CE0-0738-4433-BC3C-33E0250C3AC4

P2860

Q36469004-01B376BB-5071-4C76-9144-28F58A576CA3

Q36469004-03437F8C-66A8-40F0-9914-059DD5019916

Q36469004-04814B59-2394-4247-936E-3F212B5BDA16

Q36469004-0A3ECFCF-D32C-4F46-8013-F3E40EFF459E

Q36469004-0C51B890-2EFA-40F1-BC69-C64393AF6CAF

Q36469004-0CABBFD8-7635-4ABB-A2EE-4C4C7D697934

Q36469004-0F84CF5A-95C2-4A56-A020-49F52542B8F0

Q36469004-12047331-0E81-437D-9395-DBE1518FD2D6

Q36469004-12BFCBE3-B56D-4E32-A63D-F2C23AA61AF3

Q36469004-158B1332-0FA3-4B7D-AB53-BBFDDAA3C074

P304

Q36469004-22EE51B4-9906-465E-AFAF-3C5A82028BDC

P31

Q36469004-B5C601B5-5A2F-4374-9D79-A9857BF9D717

P356

Q36469004-A27E3DAF-016E-458C-9C5A-5FCDE9522E79

P407

Q36469004-FFBE3CF6-6595-46A7-A9A4-3887DF28BA40

P433

Q36469004-9D54A361-1D01-4DD5-8FE8-E2680D23D277

P478

Q36469004-9F5FD159-E616-4411-B861-49B62B1EE1F2

P50

Q36469004-FC256BA1-9DAA-47DD-9083-CD560E292C3E

P577

Q36469004-295B6726-1D8A-4503-893F-0B4C9213DEB5

P698

Q36469004-756F6F1C-ED52-4095-8DF2-782C2BCFC5AB

P932

Q36469004-C6DA62BB-AECB-4795-AE7A-A723F6E8EEDB

P356

P1433

Journal of the American Chemical Society

P1476

Development of α-helical calpa ...... l protein-protein interaction.

@en

P2093

Doron C Greenbaum

http://www.w3.org/2001/XMLSchema#string

Hyunil Jo

http://www.w3.org/2001/XMLSchema#string

Kristin E Low

http://www.w3.org/2001/XMLSchema#string

Nataline Meinhardt

http://www.w3.org/2001/XMLSchema#string

Peter L Davies

http://www.w3.org/2001/XMLSchema#string

Swapnil Kulkarni

http://www.w3.org/2001/XMLSchema#string

Xiaozhen Hu

http://www.w3.org/2001/XMLSchema#string

Yibing Wu

http://www.w3.org/2001/XMLSchema#string

P2860

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Cysteine cathepsins: from structure, function and regulation to new frontiers

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

Development of calpain-specific inactivators by screening of positional scanning epoxide libraries

Cocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions #

Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

The program XEASY for computer-supported NMR spectral analysis of biological macromolecules

P304

17704-17713

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1021/JA307599Z

http://www.w3.org/2001/XMLSchema#string

P407

P433

42

http://www.w3.org/2001/XMLSchema#string

P478

134

http://www.w3.org/2001/XMLSchema#string

P50

William DeGrado

P577

2012-10-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

22998171

http://www.w3.org/2001/XMLSchema#string

P932

3523126

http://www.w3.org/2001/XMLSchema#string