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ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related DiseasesRetinol as electron carrier in redox signaling, a new frontier in vitamin A researchMitochondrial aging and age-related dysfunction of mitochondriap66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosisReactive oxygen species (ROS) homeostasis and redox regulation in cellular signalingReactive oxygen species, cellular redox systems, and apoptosisZinc deficiency mediates alcohol-induced apoptotic cell death in the liver of rats through activating ER and mitochondrial cell death pathwaysThe redox protein p66(shc) mediates cochlear vascular dysfunction and transient noise-induced hearing loss.Cytoplasmic signaling in the control of mitochondrial uproar?Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene.p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgeneThe interplay between p66Shc, reactive oxygen species and cancer cell metabolism.p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy.Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic systemDiallyl trisulfide-induced prostate cancer cell death is associated with Akt/PKB dephosphorylation mediated by P-p66shc.The influence of shc proteins and aging on whole body energy expenditure and substrate utilization in miceAge-related subproteomic analysis of mouse liver and kidney peroxisomes.Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases.P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration.Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondriaThe versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death.The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos.The p66Shc adapter protein regulates the morphogenesis and epithelial maturation of fetal mouse lungs.Mitochondrial calcium homeostasis as potential target for mitochondrial medicine.Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis.Insulin resistance, diabetes, and cardiovascular risk.p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans.Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri.Vitamin A as PKC Co-factor and Regulator of Mitochondrial Energetics.Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity.Propofol attenuates high glucose-induced superoxide anion accumulation in human umbilical vein endothelial cells.p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells.The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.p53 and aging: role of p66Shc.
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Apoptosis and aging: role of p66Shc redox protein.
@ast
Apoptosis and aging: role of p66Shc redox protein.
@en
type
label
Apoptosis and aging: role of p66Shc redox protein.
@ast
Apoptosis and aging: role of p66Shc redox protein.
@en
prefLabel
Apoptosis and aging: role of p66Shc redox protein.
@ast
Apoptosis and aging: role of p66Shc redox protein.
@en
P356
P1476
Apoptosis and aging: role of p66Shc redox protein
@en
P2093
Enrica Migliaccio
Pier Giuseppe Pelicci
P304
P356
10.1089/ARS.2006.8.600
P577
2006-03-01T00:00:00Z