about
Moro orange juice prevents fatty liver in miceOxidative stress and the unfulfilled promises of antioxidant agentsRole of PML in cell growth and the retinoic acid pathwayDecreased superoxide production in macrophages of long-lived p66Shc knock-out mice.Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66(Shc-/-) mouse.The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.The influence of Shc proteins on life span in mice.p66Shc, mitochondria, and the generation of reactive oxygen species.Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors.A Role for PML in Innate ImmunityGenetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis.Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life.A novel neuroferritinopathy mouse model (FTL 498InsTC) shows progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits.Apoptosis and aging: role of p66Shc redox protein.Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.Recognition efficiency of the hepatitis B virus polyadenylation signals is tissue specific in transgenic mice.P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan.The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration.p66Shc-generated oxidative signal promotes fat accumulationOxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidase.Mitochondria and vascular pathology.p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans.Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1.Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri.New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases.Maternal Care Determinant of Longevity?Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice.Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction.The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomasThe p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.p53 and aging: role of p66Shc.A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongation.Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation.
P50
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P50
description
Forscher
@de
chercheur
@fr
investigador
@es
researcher
@en
ricercatore
@it
wetenschapper
@nl
研究者
@zh
name
Giorgio M
@ast
Giorgio M
@es
Giorgio M
@nl
Marco Giorgio
@en
type
label
Giorgio M
@ast
Giorgio M
@es
Giorgio M
@nl
Marco Giorgio
@en
altLabel
Giorgio M
@en
prefLabel
Giorgio M
@ast
Giorgio M
@es
Giorgio M
@nl
Marco Giorgio
@en
P31
P496
0000-0002-5842-6042