The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.
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Melanoma: from melanocyte to genetic alterations and clinical optionsLGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell linesA noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasisDetecting PKC phosphorylation as part of the Wnt/calcium pathway in cutaneous melanomaThe postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signalingWnt5A activates the calpain-mediated cleavage of filamin AActivation of Wnt5A signaling is required for CXC chemokine ligand 12-mediated T-cell migrationFrequent somatic mutations of GNAQ in uveal melanoma and blue naeviThe orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanomaWnt5a Signaling in CancerPromising Druggable Target in Head and Neck Squamous Cell Carcinoma: Wnt SignalingWNT-5A: signaling and functions in health and diseaseTherapy for BRAFi-Resistant Melanomas: Is WNT5A the Answer?The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3Biological functions of macrophage-derived Wnt5a, and its roles in human diseasesThe importance of Wnt signalling for neurodegeneration in Parkinson's diseaseFGF receptors: cancer biology and therapeuticsActivated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma modelJun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1Down-regulation of canonical and up-regulation of non-canonical Wnt signalling in the carcinogenic process of squamous cell lung carcinomaWNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transitionMethylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasionWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.MMP-10/stromelysin-2 promotes invasion of head and neck cancer.Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets.Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation.Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activationComparative study of ROR2 and WNT5a expression in squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder.Networks and pathways in pigmentation, health, and disease.Assaying Wnt5A-mediated invasion in melanoma cells.A novel function for vimentin: the potential biomarker for predicting melanoma hematogenous metastasis.Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy.Genetic variants of the Wnt signaling pathway as predictors of recurrence and survival in early-stage non-small cell lung cancer patientsWnt5a / planar cell polarity signaling pathway in urothelial carcinoma, a potential prognostic biomarker.Challenging role of Wnt5a and its signaling pathway in cancer metastasis (Review).WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors.Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cellsStriking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progressionFZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.
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P2860
The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The Wnt5A/protein kinase C pat ...... ial to mesenchymal transition.
@ast
The Wnt5A/protein kinase C pat ...... ial to mesenchymal transition.
@en
type
label
The Wnt5A/protein kinase C pat ...... ial to mesenchymal transition.
@ast
The Wnt5A/protein kinase C pat ...... ial to mesenchymal transition.
@en
prefLabel
The Wnt5A/protein kinase C pat ...... ial to mesenchymal transition.
@ast
The Wnt5A/protein kinase C pat ...... ial to mesenchymal transition.
@en
P2093
P2860
P356
P1476
The Wnt5A/protein kinase C pat ...... lial to mesenchymal transition
@en
P2093
Amanda D French
Ashani T Weeraratna
Brian J Nickoloff
Carrie E Johnson
Dennis D Taub
Devin T Rosenthal
Fred E Indig
Jeffrey M Trent
Kavita V Shah
Kyle J Hewitt
P2860
P304
17259-17271
P356
10.1074/JBC.M700075200
P407
P577
2007-04-10T00:00:00Z