The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.
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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerp53 protects against genome instability following centriole duplication failureThe PLK4-STIL-SAS-6 module at the core of centriole duplicationOncogene-like induction of cellular invasion from centrosome amplification.DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.The centriole duplication cycle.Causes and consequences of centrosome abnormalities in cancer.Two outward potassium current types are expressed during the neural differentiation of neural stem cellsIdentification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs.The centrosome and its duplication cycleQuantitative immunofluorescence assay to measure the variation in protein levels at centrosomes.Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer.Loss of KLF14 triggers centrosome amplification and tumorigenesis.Epidermal development, growth control, and homeostasis in the face of centrosome amplificationChronic centrosome amplification without tumorigenesis.Recent Advances and New Strategies in Targeting Plk1 for Anticancer TherapyCentrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stressTruncation of POC1A associated with short stature and extreme insulin resistanceTurning the headlights on novel cancer biomarkers: Inspection of mechanics underlying intratumor heterogeneityA USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.Quantitative analysis of human centrosome architecture by targeted proteomics and fluorescence imaging.The PIDDosome activates p53 in response to supernumerary centrosomes.Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy.The centrosome duplication cycle in health and disease.Polo-like kinases: structural variations lead to multiple functions.KinView: a visual comparative sequence analysis tool for integrated kinome research.The interplay between centrosomes and the Hippo tumor suppressor pathway.The Janus soul of centrosomes: a paradoxical role in disease?Centrosome amplification, chromosomal instability and cancer: mechanistic, clinical and therapeutic issues.Centrosomal clustering contributes to chromosomal instability and cancer.Binding of STIL to Plk4 activates kinase activity to promote centriole assemblyCytokinesis failure triggers hippo tumor suppressor pathway activation.Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals.Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein.A New Mode of Mitotic Surveillance.Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells.The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis.
P2860
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P2860
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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name
The autoregulated instability ...... cation to once per cell cycle.
@ast
The autoregulated instability ...... cation to once per cell cycle.
@en
type
label
The autoregulated instability ...... cation to once per cell cycle.
@ast
The autoregulated instability ...... cation to once per cell cycle.
@en
prefLabel
The autoregulated instability ...... cation to once per cell cycle.
@ast
The autoregulated instability ...... cation to once per cell cycle.
@en
P2093
P2860
P50
P356
P1433
P1476
The autoregulated instability ...... cation to once per cell cycle.
@en
P2093
Andrew J Holland
Inder M Verma
Manuel Bauer
P2860
P304
P356
10.1101/GAD.207027.112
P577
2012-12-01T00:00:00Z