PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.
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IRF7: activation, regulation, modification and functionThe effects of TLR activation on T-cell development and differentiationThe plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functionsContribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosusMolecular Determinants of GS-9620-Dependent TLR7 ActivationPIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signalingTreatment of primary Sjögren syndrome.Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functionsTargeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease.The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma.Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses.High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors.Toll-like receptor signaling in cell proliferation and survivalCharacterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies.TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFNSelective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.Plasmacytoid dendritic cells in HIV infection: striking a delicate balance.An essential role of PI3K in the control of West Nile virus infection.Type I interferon in the pathogenesis of lupus.Influenza-induced production of interferon-alpha is defective in geriatric individuals.Modulation of adaptive immunity with Toll-like receptorsPhosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophagesPlasmacytoid dendritic cells: recent progress and open questionsTLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domainTargeting of type I interferon in systemic autoimmune diseasesCurrent humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Highly specialized role of Forkhead box O transcription factors in the immune system.Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells.Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responsesDeoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based VaccineImpaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus.Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells.BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cellsIdentification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cellsToll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activityMitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA.PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma.
P2860
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P2860
PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
PI3K is critical for the nucle ...... in response to TLR activation.
@ast
PI3K is critical for the nucle ...... in response to TLR activation.
@en
type
label
PI3K is critical for the nucle ...... in response to TLR activation.
@ast
PI3K is critical for the nucle ...... in response to TLR activation.
@en
prefLabel
PI3K is critical for the nucle ...... in response to TLR activation.
@ast
PI3K is critical for the nucle ...... in response to TLR activation.
@en
P2093
P2860
P356
P1476
PI3K is critical for the nucle ...... in response to TLR activation.
@en
P2093
Cristiana Guiducci
Cristina Ghirelli
Franck J Barrat
Marie-Annick Marloie-Provost
Robert L Coffman
Tracy Matray
Vassili Soumelis
Yong-Jun Liu
P2860
P304
P356
10.1084/JEM.20070763
P407
P577
2008-01-28T00:00:00Z