PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. - Wikidata - awgldk - TriplyDB

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.

http://www.wikidata.org/entity/Q36502812

about

IRF7: activation, regulation, modification and function The effects of TLR activation on T-cell development and differentiation The plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functions Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus Molecular Determinants of GS-9620-Dependent TLR7 Activation PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling Treatment of primary Sjögren syndrome.Recent insights into the implications of metabolism in plasmacytoid dendritic cell innate functions: Potential ways to control these functions Targeting PI3K-p110α Suppresses Influenza Virus Infection in Chronic Obstructive Pulmonary Disease.The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma.Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses.High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors.Toll-like receptor signaling in cell proliferation and survival Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies.TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.Plasmacytoid dendritic cells in HIV infection: striking a delicate balance.An essential role of PI3K in the control of West Nile virus infection.Type I interferon in the pathogenesis of lupus.Influenza-induced production of interferon-alpha is defective in geriatric individuals.Modulation of adaptive immunity with Toll-like receptors Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages Plasmacytoid dendritic cells: recent progress and open questions TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.Innate immune response of human plasmacytoid dendritic cells to poxvirus infection is subverted by vaccinia E3 via its Z-DNA/RNA binding domain Targeting of type I interferon in systemic autoimmune diseases Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis.Highly specialized role of Forkhead box O transcription factors in the immune system.Unabated adenovirus replication following activation of the cGAS/STING-dependent antiviral response in human cells.Deficiency in either 4E-BP1 or 4E-BP2 augments innate antiviral immune responses Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus.Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFα release via RAGE- and TLR9-responsive plasmacytoid dendritic cells.BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA.PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma.

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P2860

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.

http://www.wikidata.org/entity/Q36502812

description

2008 nî lūn-bûn

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Journal of Experimental Medicine

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P2093

Cristiana Guiducci

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Cristina Ghirelli

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Franck J Barrat

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Marie-Annick Marloie-Provost

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Robert L Coffman

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Tracy Matray

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Vassili Soumelis

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Yong-Jun Liu

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P2860

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction

Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

Phosphoinositide 3-kinase: diverse roles in immune cell activation

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

IRF-7 is the master regulator of type-I interferon-dependent immune responses

Autophagy-dependent viral recognition by plasmacytoid dendritic cells

IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors

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315-322

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10.1084/JEM.20070763

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2

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205

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2008-01-28T00:00:00Z

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5625071

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18227218

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Toll-like receptor

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2271003

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