about
Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)De novo discovery of serotonin N-acetyltransferase inhibitorsCan Invalid Bioactives Undermine Natural Product-Based Drug Discovery?Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadDIdentification and Optimization of PDE10A Inhibitors Using Fragment-Based Screening by Nanocalorimetry and X-ray CrystallographyRedox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moietyHigh-throughput screening for novel inhibitors of Neisseria gonorrhoeae penicillin-binding protein 2Discovery of novel GPVI receptor antagonists by structure-based repurposingBiochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug targetIn Vitro and In Vivo Characterization of the Alkaloid NuciferineEpigenetic assays for chemical biology and drug discovery.PoLi: A Virtual Screening Pipeline Based on Template Pocket and Ligand Similarity.Exploiting open data: a new era in pharmacoinformatics.Docking Screens for Novel Ligands Conferring New Biology.Comparison of small molecule inhibitors of the bacterial cell division protein FtsZ and identification of a reliable cross-species inhibitor.A double-headed cathepsin B inhibitor devoid of warhead.Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.Integration of small-molecule discovery in academic biomedical researchUse of flow cytometric methods to quantify protein-protein interactions.Prediction of potency of protease inhibitors using free energy simulations with polarizable quantum mechanics-based ligand charges and a hybrid water model.nBioChip, a Lab-on-a-Chip Platform of Mono- and Polymicrobial Biofilms for High-Throughput Downstream Applications.New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria.Development of a novel high-throughput screen and identification of small-molecule inhibitors of the Gα-RGS17 protein-protein interaction using AlphaScreen.Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG).Guiding principles for natural product drug discovery.Quantifying and predicting the promiscuity and isoform specificity of small-molecule cytochrome P450 inhibitors.Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpBHTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pocketsFluorescence polarization assays in small molecule screening.Disordered binding of small molecules to Aβ(12-28).Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.Screening-based approaches to identify small molecules that inhibit protein-protein interactions.Drug repositioning for personalized medicine.The promiscuous protein binding ability of erythrosine B studied by metachromasy (metachromasia).
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Screening in a spirit haunted world.
@ast
Screening in a spirit haunted world.
@en
type
label
Screening in a spirit haunted world.
@ast
Screening in a spirit haunted world.
@en
prefLabel
Screening in a spirit haunted world.
@ast
Screening in a spirit haunted world.
@en
P2860
P1433
P1476
Screening in a spirit haunted world.
@en
P2093
Brian K Shoichet
P2860
P304
P356
10.1016/J.DRUDIS.2006.05.014
P577
2006-07-01T00:00:00Z