PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis. - Wikidata - awgldk - TriplyDB

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.

http://www.wikidata.org/entity/Q36534385

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The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2 DUBs, New Members in the Hypoxia Signaling clUb Hypoxia and metabolic adaptation of cancer cells Immunometabolism in Tuberculosis Arsenite-induced pseudo-hypoxia results in loss of anchorage-dependent growth in BEAS-2B pulmonary epithelial cells Mild hypoxia-induced cardiomyocyte hypertrophy via up-regulation of HIF-1α-mediated TRPC signalling Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea.Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.Oxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha.Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP.HIF1α and pancreatic β-cell development.Distinct roles of HIF1A in endothelial adaptations to physiological and ambient oxygen.Involvement of net and Hif1alpha in distinct yet intricately linked hypoxia-induced signaling pathways.Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival Prolyl hydroxylase PHD3 enhances the hypoxic survival and G1 to S transition of carcinoma cells.ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha.Redox signaling in cardiac myocytes.Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues Molecular characterization and mRNA expression of two key enzymes of hypoxia-sensing pathways in eastern oysters Crassostrea virginica (Gmelin): hypoxia-inducible factor α (HIF-α) and HIF-prolyl hydroxylase (PHD).Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes.The prolyl hydroxylase enzymes are positively associated with hypoxia-inducible factor-1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen.Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability Antenatal maternal long-term hypoxia: acclimatization responses with altered gene expression in ovine fetal carotid arteries.Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.Metabolic Profiles in Ovine Carotid Arteries with Developmental Maturation and Long-Term Hypoxia.Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling.An integer linear programming approach for finding deregulated subgraphs in regulatory networks.HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer Cardiac angiogenesis directed by stable Hypoxia Inducible Factor-1.Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish Wound healing essentials: let there be oxygen The role of HIF prolyl hydroxylases in tumour growth.cAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1.Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.Hypoxia inducible factor-2alpha: a critical mediator of aggressive tumor phenotypes.

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P2860

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.

http://www.wikidata.org/entity/Q36534385

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

PHDs overactivation during chr ...... protects cells from necrosis.

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PHDs overactivation during chr ...... protects cells from necrosis.

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type

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PHDs overactivation during chr ...... protects cells from necrosis.

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PHDs overactivation during chr ...... protects cells from necrosis.

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prefLabel

PHDs overactivation during chr ...... protects cells from necrosis.

@ast

PHDs overactivation during chr ...... protects cells from necrosis.

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PHDs overactivation during chr ...... protects cells from necrosis.

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P2093

Amandine Ginouvès

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Edurne Berra

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Karine Ilc

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Nuria Macías

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Oxygen sensing by HIF hydroxylases

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4745-4750

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12

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Jacques Pouysségur

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5505819

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18347341

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