An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.
about
Simple and straightforward construction of a mouse gene targeting vector using in vitro transposition reactionsViral bacterial artificial chromosomes: generation, mutagenesis, and removal of mini-F sequencesThe transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomesLaron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse.Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle developmentProtamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cellsConditional and inducible gene recombineering in the mouse inner earA gene expression resource generated by genome-wide lacZ profiling in the mouse.Directed evolution of the site specificity of Cre recombinase.The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Transcriptional interference by independently regulated genes occurs in any relative arrangement of the genes and is influenced by chromosomal integration position.Brief expression of a GFP cre fusion gene in embryonic stem cells allows rapid retrieval of site-specific genomic deletionsIntra-chromosomal rearrangements generated by Cre-lox site-specific recombination.Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.Olfactory receptor genes expressed in distinct lineages are sequestered in different nuclear compartments.Use of double-replacement gene targeting to replace the murine alpha-lactalbumin gene with its human counterpart in embryonic stem cells and mice.Long-range disruption of gene expression by a selectable marker cassette.Inducible LAP-tagged Stable Cell Lines for Investigating Protein Function, Spatiotemporal Localization and Protein Interaction Networks.Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.Recombinase technology: applications and possibilitiesExogenous enzymes upgrade transgenesis and genetic engineering of farm animals.Expression of the (recombinant) endogenous immunoglobulin heavy-chain locus requires the intronic matrix attachment regions.Variegated expression of the endogenous immunoglobulin heavy-chain gene in the absence of the intronic locus control region.FLP-mediated recombination of FRT sites in the maize genome.Convenient and reversible site-specific targeting of exogenous DNA into a bacterial chromosome by use of the FLP recombinase: the FLIRT system.Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.NF-E2 and GATA binding motifs are required for the formation of DNase I hypersensitive site 4 of the human beta-globin locus control region.Genetically engineered mice: tools to understand craniofacial development.Gene knockout and transgenic technologies in risk assessment: the next generation.Analyses of transcription factor CP2 expression during development and differentiation
P2860
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P2860
An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
An "in-out" strategy using gen ...... a-globin locus control region.
@ast
An "in-out" strategy using gen ...... a-globin locus control region.
@en
type
label
An "in-out" strategy using gen ...... a-globin locus control region.
@ast
An "in-out" strategy using gen ...... a-globin locus control region.
@en
prefLabel
An "in-out" strategy using gen ...... a-globin locus control region.
@ast
An "in-out" strategy using gen ...... a-globin locus control region.
@en
P2093
P2860
P356
P1476
An "in-out" strategy using gen ...... a-globin locus control region.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.18.8469
P407
P577
1993-09-01T00:00:00Z