Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site
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Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeastCloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expressionIsolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control regionhMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2Methyl binding domain protein 2 mediates gamma-globin gene silencing in adult human betaYAC transgenic miceNRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and developmentEffect of deletion of 5'HS3 or 5'HS2 of the human beta-globin locus control region on the developmental regulation of globin gene expression in beta-globin locus yeast artificial chromosome transgenic mice.Phylogenetic footprinting reveals a nuclear protein which binds to silencer sequences in the human gamma and epsilon globin genesThe locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells.Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.Beta-globin locus activation regions: conservation of organization, structure, and functionSynergistic enhancement of globin gene expression by activator protein-1-like proteins.Inactivation of human alpha-globin gene expression by a de novo deletion located upstream of the alpha-globin gene clusterThe beta-globin dominant control region: hypersensitive site 2Detailed analysis of the site 3 region of the human beta-globin dominant control regionAnalysis of the human alpha globin upstream regulatory element (HS-40) in transgenic miceSynthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.Generation of a high-titer retroviral vector capable of expressing high levels of the human beta-globin gene.Hypoxia-induced in vivo sickling of transgenic mouse red cells.Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.Multiple elements in human beta-globin locus control region 5' HS 2 are involved in enhancer activity and position-independent, transgene expressionRetroviral vector sequences inhibit human beta-globin gene expression in transgenic mice.A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation.A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expressionDevelopmental regulation of the human zeta globin gene in transgenic mice.Binary transgenic mouse model for studying the trans control of globin gene switching: evidence that GATA-1 is an in vivo repressor of human epsilon gene expressionSynergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase.Rhabdomyosarcoma arising in transgenic mice harboring the beta-globin locus control region fused with simian virus 40 large T antigen gene.Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region.Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene.Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice.Activation of the beta-globin promoter by the locus control region correlates with binding of a novel factor to the CAAT box in murine erythroleukemia cells but not in K562 cells.A 36-base-pair core sequence of locus control region enhances retrovirally transferred human beta-globin gene expression.Activation of the beta-globin locus control region precedes commitment to the erythroid lineage.Transcription of the hypersensitive site HS2 enhancer in erythroid cells.Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice
P2860
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P2860
Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site
description
1989 nî lūn-bûn
@nan
1989 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Human beta-globin gene express ...... nt DNase I hypersensitive site
@ast
Human beta-globin gene express ...... nt DNase I hypersensitive site
@en
Human beta-globin gene express ...... nt DNase I hypersensitive site
@nl
type
label
Human beta-globin gene express ...... nt DNase I hypersensitive site
@ast
Human beta-globin gene express ...... nt DNase I hypersensitive site
@en
Human beta-globin gene express ...... nt DNase I hypersensitive site
@nl
prefLabel
Human beta-globin gene express ...... nt DNase I hypersensitive site
@ast
Human beta-globin gene express ...... nt DNase I hypersensitive site
@en
Human beta-globin gene express ...... nt DNase I hypersensitive site
@nl
P2093
P2860
P356
P1476
Human beta-globin gene express ...... nt DNase I hypersensitive site
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.18.7082
P407
P577
1989-09-01T00:00:00Z