Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
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Rac and Rho GTPases in cancer cell motility controlRational design of small molecule inhibitors targeting RhoA subfamily Rho GTPasesStructural Mechanisms and Drug Discovery Prospects of Rho GTPasesRas conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamicsA comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoniIdentification of potential small molecule binding pockets on Rho family GTPasesNovel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPasesNovel aspects of the roles of Rac1 GTPase in the cardiovascular systemK-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activityPhosphorylation of α-tubulin by protein kinase C stimulates microtubule dynamics in human breast cellsPhosphorylation of Cdc42 effector protein-4 (CEP4) by protein kinase C promotes motility of human breast cellsA competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibitionIdentification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity.A switch I mutant of Cdc42 exhibits less conformational freedom.Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathyMapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm.Characterization of EHop-016, novel small molecule inhibitor of Rac GTPaseThe Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.IL-15 regulates migration, invasion, angiogenesis and genes associated with lipid metabolism and inflammation in prostate cancer.Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins.Lamellipodia are crucial for haptotactic sensing and response.PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.Rac Regulates Giardia lamblia Encystation by Coordinating Cyst Wall Protein Trafficking and Secretion.The ubiquitin-like protein LC3 regulates the Rho-GEF activity of AKAP-LbcImplications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.Number of expressed cancer/testis antigens identifies focal adhesion pathway genes as possible targets for multiple myeloma therapy.Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.Direct Modulation of Small GTPase Activity and Function.The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer.ASIC-like currents in freshly isolated cerebral artery smooth muscle cells are inhibited by endogenous oxidase activity.Mediation of Rac1 activation by kindlin-2: an essential function in osteoblast adhesion, spreading, and proliferation.MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades.Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2.Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma.Remedial strategies in structural proteomics: expression, purification, and crystallization of the Vav1/Rac1 complex.Molecular pathways: targeting the kinase effectors of RHO-family GTPases.Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.
P2860
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P2860
Structure-function based design of small molecule inhibitors targeting Rho family GTPases.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Structure-function based desig ...... targeting Rho family GTPases.
@ast
Structure-function based desig ...... targeting Rho family GTPases.
@en
type
label
Structure-function based desig ...... targeting Rho family GTPases.
@ast
Structure-function based desig ...... targeting Rho family GTPases.
@en
prefLabel
Structure-function based desig ...... targeting Rho family GTPases.
@ast
Structure-function based desig ...... targeting Rho family GTPases.
@en
P2093
P1476
Structure-function based desig ...... targeting Rho family GTPases.
@en
P2093
David A Williams
Jose Cancelas
Nicolas Nassar
P304
P356
10.2174/156802606777812095
P577
2006-01-01T00:00:00Z