Predicting enhanced cell killing through PARP inhibition.
about
Genome-wide profiling of genetic synthetic lethality identifies CDK12 as a novel determinant of PARP1/2 inhibitor sensitivity.Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair researchEnhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for CancerRationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition.Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.Base excision repair defects invoke hypersensitivity to PARP inhibition.Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cellsMajor differences between tumor and normal human cell fates after exposure to chemotherapeutic monofunctional alkylatorDNA polymerase β-dependent cell survival independent of XRCC1 expressionInitial testing (stage 1) of the PARP inhibitor BMN 673 by the pediatric preclinical testing program: PALB2 mutation predicts exceptional in vivo response to BMN 673.Consequence of the tumor-associated conversion to cyclin D1bSynergistic activity of PARP inhibition by talazoparib (BMN 673) with temozolomide in pediatric cancer models in the pediatric preclinical testing program.Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced CytotoxicityPreventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses.Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration.Personalized nanomedicine: future medicine for cancer treatment.XRCC1-mediated repair of strand breaks independent of PNKP binding.PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors.
P2860
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P2860
Predicting enhanced cell killing through PARP inhibition.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Predicting enhanced cell killing through PARP inhibition.
@ast
Predicting enhanced cell killing through PARP inhibition.
@en
type
label
Predicting enhanced cell killing through PARP inhibition.
@ast
Predicting enhanced cell killing through PARP inhibition.
@en
prefLabel
Predicting enhanced cell killing through PARP inhibition.
@ast
Predicting enhanced cell killing through PARP inhibition.
@en
P2860
P1476
Predicting enhanced cell killing through PARP inhibition.
@en
P2093
Julie K Horton
Samuel H Wilson
P2860
P356
10.1158/1541-7786.MCR-12-0512
P577
2012-11-27T00:00:00Z