XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. - Wikidata - awgldk - TriplyDB

XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.

XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.

http://www.wikidata.org/entity/Q36629377

about

The interaction between the PARP10 protein and the NS1 protein of H5N1 AIV and its effect on virus replication Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility Role of Deubiquitinating Enzymes in DNA Repair Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase binding affinity The structural basis of XRCC1-mediated DNA repair Tumor growth is suppressed in mice expressing a truncated XRCC1 protein Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5.The multi-replication protein A (RPA) system--a new perspective.Prognostic and predictive role of COX-2, XRCC1 and RASSF1 expression in patients with esophageal squamous cell carcinoma receiving radiotherapy ERCC1, XRCC1 and GSTP1 Single Nucleotide Polymorphisms and Survival of Patients with Colon Cancer Receiving Oxaliplatin-Based Adjuvant Chemotherapy.The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.Irreversible inhibition of DNA polymerase β by small-molecule mimics of a DNA lesion DNA breaks and chromosomal aberrations arise when replication meets base excision repair.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Recombination phenotypes of the NCI-60 collection of human cancer cells.Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.Base excision repair defects invoke hypersensitivity to PARP inhibition.Mammalian base excision repair: the forgotten archangel Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts.Base excision repair capacity in informing healthspan.Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.Clinical significance of a point mutation in DNA polymerase beta (POLB) gene in gastric cancer Genetic susceptibility to benzene toxicity in humans.DNA polymerase β-dependent cell survival independent of XRCC1 expression DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair The ups and downs of DNA repair biomarkers for PARP inhibitor therapies Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts.Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation.Base excision repair and design of small molecule inhibitors of human DNA polymerase β.Poly (ADP-ribose) polymerase inhibitors: recent advances and future development.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.Contracting CAG/CTG repeats using the CRISPR-Cas9 nickase.DNA repair gene ERCC1 C118T polymorphism predicts sensitivity of recurrent esophageal cancer to radiochemotherapy in a Chinese population.Evidence for abasic site sugar phosphate-mediated cytotoxicity in alkylating agent treated Saccharomyces cerevisiae

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P2860

XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.

http://www.wikidata.org/entity/Q36629377

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

XRCC1 and DNA polymerase beta ...... oxic DNA single-strand breaks.

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XRCC1 and DNA polymerase beta ...... oxic DNA single-strand breaks.

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type

label

XRCC1 and DNA polymerase beta ...... oxic DNA single-strand breaks.

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XRCC1 and DNA polymerase beta ...... oxic DNA single-strand breaks.

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XRCC1 and DNA polymerase beta ...... oxic DNA single-strand breaks.

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XRCC1 and DNA polymerase beta ...... oxic DNA single-strand breaks.

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XRCC1 and DNA polymerase beta ...... oxic DNA single-strand breaks.

@en

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Daniel T Shaughnessy

http://www.w3.org/2001/XMLSchema#string

Donna F Stefanick

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Julie K Horton

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Mary Watson

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Samuel H Wilson

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P2860

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

Instability and decay of the primary structure of DNA

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate ends

Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

The FHA domain of aprataxin interacts with the C-terminal region of XRCC1

Domain specific interaction in the XRCC1-DNA polymerase beta complex

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48-63

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10.1038/CR.2008.7

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1

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18

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5682694

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18166976

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2366203

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