RAS signalling is abnormal in a c-raf1 MEK1 double mutant
about
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalingInteraction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cellsGenetic analysis of Ras signalling pathways in cell proliferation, migration and survival.Hypothermic stress leads to activation of Ras-Erk signalingp16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinomaActivation of the p42 mitogen-activated protein kinase pathway inhibits Cdc2 activation and entry into M-phase in cycling Xenopus egg extracts.Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence.Using cells devoid of RAS proteins as tools for drug discovery.Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells.Mutations in conserved regions 1, 2, and 3 of Raf-1 that activate transforming activity.Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobility.Inactivation of p42 mitogen-activated protein kinase is required for exit from M-phase after cyclin destruction.
P2860
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P2860
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
@ast
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
@en
type
label
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
@ast
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
@en
prefLabel
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
@ast
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
@en
P2093
P2860
P356
P1476
RAS signalling is abnormal in a c-raf1 MEK1 double mutant
@en
P2093
P2860
P304
P356
10.1128/MCB.15.9.5113
P407
P577
1995-09-01T00:00:00Z