Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. - Wikidata - awgldk - TriplyDB

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

http://www.wikidata.org/entity/Q39541632

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mTOR-dependent cell survival mechanisms Pathways and therapeutic targets in melanoma Alternative fuels for cancer cells Adapt, Recycle, and Move on: Proteostasis and Trafficking Mechanisms in Melanoma Drugging the addict: non-oncogene addiction as a target for cancer therapy Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication.High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling C10ORF10/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy.Single amino acid arginine deprivation triggers prosurvival autophagic response in ovarian carcinoma SKOV3 Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib Quantitative indices of autophagy activity from minimal models.Multiple metabolic alterations exist in mutant PI3K cancers, but only glucose is essential as a nutrient source Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.Maintenance of melanophore morphology and survival is cathepsin and vps11 dependent in zebrafish.Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells.The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death.The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.The role for autophagy in cancer.Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis The dynamic nature of autophagy in cancer The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.Elevated PI3K signaling drives multiple breast cancer subtypes.Autophagy proteins play cytoprotective and cytocidal roles in leucine starvation-induced cell death in Saccharomyces cerevisiae.Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21.Autophagy is a protective mechanism for human melanoma cells under acidic stress.Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate.Therapeutic interventions to disrupt the protein synthetic machinery in melanoma Regulation of Histone Acetylation by Autophagy in Parkinson Disease Enhanced autophagy in cytarabine arabinoside-resistant U937 leukemia cells and its potential as a target for overcoming resistance.Soy-Based Multiple Amino Acid Oral Supplementation Increases the Anti-Sarcoma Effect of Cyclophosphamide.Deconvoluting the context-dependent role for autophagy in cancer Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy.Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas.

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P2860

Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo.

http://www.wikidata.org/entity/Q39541632

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Defective regulation of autoph ...... ma cells in vitro and in vivo.

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Joon-Ho Sheen

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Roberto Zoncu

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P2860

The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Inhibition of macroautophagy triggers apoptosis

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website

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