Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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P1476

Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs

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P2093

Richard J Youle

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P2860

Premature ageing in mice expressing defective mitochondrial DNA polymerase

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions.

New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice.

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria.

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations.

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.

Tissue- and cell-type-specific manifestations of heteroplasmic mtDNA 3243A>G mutation in human induced pluripotent stem cell-derived disease model.

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

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R1052-4

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scholarly article

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10.1016/J.CUB.2013.10.048

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English

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Alicia M Pickrell

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2013-12-01T00:00:00Z

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259204662

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24309284

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4746723

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