Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
about
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckProtein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylationZAP70: a master regulator of adaptive immunityTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationCbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.The Syk family of protein tyrosine kinases in T-cell activation and developmentSHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsCbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding.The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Tyrosines in the carboxyl terminus regulate Syk kinase activity and functionActivation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP).Cbl: many adaptations to regulate protein tyrosine kinases.The structure, regulation, and function of ZAP-70.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domainsAllelic variant in CTLA4 alters T cell phosphorylation patternsc-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell developmentT cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase.A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinaseThe Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction.ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia.Syk and pTyr'd: Signaling through the B cell antigen receptorZAP-70: an essential kinase in T-cell signalingTyrosine phosphorylation mediates both activation and downmodulation of the biological activity of VavInteraction between CD45-AP and protein-tyrosine kinases involved in T cell receptor signaling.Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association.Tyrosine 315 determines optimal recruitment of ZAP-70 to the T cell antigen receptor.T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase
P2860
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P2860
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
@ast
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
@en
type
label
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
@ast
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
@en
prefLabel
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
@ast
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
@en
P2860
P356
P1476
Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.
@en
P2860
P304
P356
10.1128/MCB.16.12.6765
P407
P577
1996-12-01T00:00:00Z