The structure, regulation, and function of ZAP-70. - Wikidata - awgldk - TriplyDB

The structure, regulation, and function of ZAP-70.

The structure, regulation, and function of ZAP-70.

http://www.wikidata.org/entity/Q34605479

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T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells Comparative Anatomy of Phagocytic and Immunological Synapses Functional roles of Syk in macrophage-mediated inflammatory responses αβ TCR-mediated recognition: relevance to tumor-antigen discovery and cancer immunotherapy Asymmetric PTEN distribution regulated by spatial heterogeneity in membrane-binding state transitions Genetics of SCID Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70 Phosphorylation site dynamics of early T-cell receptor signaling The Structural Basis for Activation and Inhibition of ZAP-70 Kinase Domain Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.Neutrophil cell surface receptors and their intracellular signal transduction pathways.Non-degradative Ubiquitination of Protein Kinases.Biophysical mechanism of T-cell receptor triggering in a reconstituted system Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Long-Term Outcomes of Hematopoietic Stem Cell Transplantation for ZAP70 Deficiency.Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.Organization of proximal signal initiation at the TCR:CD3 complex.T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.ITAM-mediated signaling by the T-cell antigen receptor Cbl enforces Vav1 dependence and a restricted pathway of T cell development Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.T-cell signaling regulated by the Tec family kinase, Itk.Quantitative analysis of protein phosphorylations and interactions by multi-colour IP-FCM as an input for kinetic modelling of signalling networks Tyrosines in the carboxyl terminus regulate Syk kinase activity and function Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells.Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells.A conserved isoleucine maintains the inactive state of Bruton's tyrosine kinase Constitutively active Lck kinase in T cells drives antigen receptor signal transduction Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus Cytokine profile, proliferation and phosphorylation of ERK1/2 and Akt in circulating mononuclear cells from individuals during the chronic intestinal phase of Schistosomiasis mansoni infection Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells.Phospho-flow cytometry based analysis of differences in T cell receptor signaling between regulatory T cells and CD4+ T cells.Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime.The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.T cell receptor signaling that regulates the development of intrathymic natural regulatory T cells.

P2860

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P2860

The structure, regulation, and function of ZAP-70.

http://www.wikidata.org/entity/Q34605479

description

2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի մարտին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

The structure, regulation, and function of ZAP-70.

@ast

The structure, regulation, and function of ZAP-70.

@en

The structure, regulation, and function of ZAP-70.

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type

label

The structure, regulation, and function of ZAP-70.

@ast

The structure, regulation, and function of ZAP-70.

@en

The structure, regulation, and function of ZAP-70.

@nl

prefLabel

The structure, regulation, and function of ZAP-70.

@ast

The structure, regulation, and function of ZAP-70.

@en

The structure, regulation, and function of ZAP-70.

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P356

J.1600-065X.2008.00753.X

P1433

Immunological Reviews

P1476

The structure, regulation, and function of ZAP-70

@en

P2093

Emil H Palacios

http://www.w3.org/2001/XMLSchema#string

John Kuriyan

http://www.w3.org/2001/XMLSchema#string

Lih-Yun Hsu

http://www.w3.org/2001/XMLSchema#string

Susan E Levin

http://www.w3.org/2001/XMLSchema#string

P2860

Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein

Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.

Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.

Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70.

Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70.

Regulation of beta 1 integrin-mediated adhesion by T cell receptor signaling involves ZAP-70 but differs from signaling events that regulate transcriptional activity.

T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.

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41-57

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scholarly article

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10.1111/J.1600-065X.2008.00753.X

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1

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228

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Byron B Au-Yeung

Sebastian Deindl

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2009-03-01T00:00:00Z

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19290920

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