Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity.
about
Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsPhloretin-induced changes of lipophilic ion transport across the plasma membrane of mammalian cells.Membrane interactions of a self-assembling model peptide that mimics the self-association, structure and toxicity of Abeta(1-40).Kinetic study of beta-amyloid residue accessibility using reductive alkylation and mass spectrometry.Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange.Exploring the mechanism of beta-amyloid toxicity attenuation by multivalent sialic acid polymers through the use of mathematical models.Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease.Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.A yeast toxic mutant of HET-s((218-289)) prion displays alternative intermediates of amyloidogenesisStructure of A beta(25-35) peptide in different environmentsAlzheimer's disease and Abeta toxicity: from top to bottom.Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.A glycine zipper motif mediates the formation of toxic β-amyloid oligomers in vitro and in vivo.Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathologyAttenuation of beta-amyloid-induced toxicity by sialic-acid-conjugated dendrimers: role of sialic acid attachment.Europium as an inhibitor of Amyloid-β(1-42) induced membrane permeationReactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives.Neurosteroids block the increase in intracellular calcium level induced by Alzheimer’s β-amyloid protein in long-term cultured rat hippocampal neurons.Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate.Amino acid substitutions [K16A] and [K28A] distinctly affect amyloid β-protein oligomerization.Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.Amyloid β-protein oligomers and Alzheimer's disease.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.Aβ oligomer-induced synapse degeneration in Alzheimer's disease.Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems.Perspectives on Inhibiting β-Amyloid Aggregation through Structure-Based Drug Design.Glucose directs amyloid-beta into membrane-active oligomers.Thermodynamically stable amyloid-β monomers have much lower membrane affinity than the small oligomers.Structurally distinct toxicity inhibitors bind at common loci on β-amyloid fibril.The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor.A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.Changes of enzyme activity in lipid signaling pathways related to substrate reordering.Effect of amyloid beta-peptide on permeability transition pore: a comparative study.Cholesterol attenuates the membrane perturbing properties of beta-amyloid peptides.Apoptotic neuronal cell death induced by the non-fibrillar amyloid-beta peptide proceeds through an early reactive oxygen species-dependent cytoskeleton perturbation.Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes.Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity.Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation.Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes.
P2860
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P2860
Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Inhibition of the electrostati ...... beta-amyloid-induced toxicity.
@ast
Inhibition of the electrostati ...... beta-amyloid-induced toxicity.
@en
type
label
Inhibition of the electrostati ...... beta-amyloid-induced toxicity.
@ast
Inhibition of the electrostati ...... beta-amyloid-induced toxicity.
@en
prefLabel
Inhibition of the electrostati ...... beta-amyloid-induced toxicity.
@ast
Inhibition of the electrostati ...... beta-amyloid-induced toxicity.
@en
P2093
P2860
P356
P1476
Inhibition of the electrostati ...... beta-amyloid-induced toxicity.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.17.9412
P407
P577
1997-08-01T00:00:00Z