Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
about
CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffoldsCrystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infectionsComparative analysis of P450 signature motifs EXXR and CXG in the large and diverse kingdom of fungi: identification of evolutionarily conserved amino acid patterns characteristic of P450 familyStructural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruziSubstrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantumStructural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterolAntifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITYStructural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its InhibitionRegulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51.Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growthGenetic variation in plant CYP51s confers resistance against voriconazole, a novel inhibitor of brassinosteroid-dependent sterol biosynthesisCYB5D2 requires heme-binding to regulate HeLa cell growth and confer survival from chemotherapeutic agentsDevelopment of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas DiseaseTrypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental ModelDistinctive expansion of gene families associated with plant cell wall degradation, secondary metabolism, and nutrient uptake in the genomes of grapevine trunk pathogensFungal cytochrome p450 monooxygenases: their distribution, structure, functions, family expansion, and evolutionary originSterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasisBiosynthesis of cholesterol and other sterolsEcotoxicity of climbazole, a fungicide contained in antidandruff shampooTriazole Resistance in Aspergillus Species: An Emerging Problem.Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.The CYP51F1 Gene of Leptographium qinlingensis: Sequence Characteristic, Phylogeny and Transcript Levels.Genome-wide identification and characterization of cytochrome P450 monooxygenase genes in the ciliate Tetrahymena thermophila.The Mycobacterium tuberculosis cytochrome P450 system.Evaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner.Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylaseThe first virally encoded cytochrome p450Active DNA demethylation: many roads lead to Rome.Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).Immunoproteome of Aspergillus fumigatus using sera of patients with invasive aspergillosisStructural basis for conservation in the CYP51 family.S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling.Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51)Resistance to antifungals that target CYP51.CYP105-diverse structures, functions and roles in an intriguing family of enzymes in Streptomyces.Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.Identification and analysis of CYP7A1, CYP17A1, CYP20A1, CYP27A1 and CYP51A1 in cynomolgus macaquesIdentification and functional characterization of the CYP51 gene from the yeast Xanthophyllomyces dendrorhous that is involved in ergosterol biosynthesisAzole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)
P2860
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P2860
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
@ast
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
@en
type
label
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
@ast
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
@en
prefLabel
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
@ast
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
@en
P2860
P1476
Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms
@en
P2093
Galina I Lepesheva
Michael R Waterman
P2860
P304
P356
10.1016/J.BBAGEN.2006.07.018
P407
P577
2006-08-02T00:00:00Z