Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens. - Wikidata - awgldk - TriplyDB

Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.

Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.

http://www.wikidata.org/entity/Q30318077

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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer R -Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi Epidemiological and Genomic Landscape of Azole Resistance Mechanisms in Aspergillus Fungi Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals Fungal cytochrome p450 monooxygenases: their distribution, structure, functions, family expansion, and evolutionary origin Proposal for a unified nomenclature for target-site mutations associated with resistance to fungicides Identification of ABC transporter genes of Fusarium graminearum with roles in azole tolerance and/or virulence.The CYP51F1 Gene of Leptographium qinlingensis: Sequence Characteristic, Phylogeny and Transcript Levels.De novo Transcriptome Assembly of Phomopsis liquidambari Provides Insights into Genes Associated with Different Lifestyles in Rice (Oryza sativa L.).Activity of the novel fungicide SYP-Z048 against plant pathogens.Drug strategies targeting CYP51 in neglected tropical diseases Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.Co-Occurrence of Two Allelic Variants of CYP51 in Erysiphe necator and Their Correlation with Over-Expression for DMI Resistance.Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase Metabolic activities of five botryticides against Botrytis cinerea examined using the Biolog FF MicroPlate Synthesis, Biological Evaluation, and Molecular Modeling Studies of New Oxadiazole-Stilbene Hybrids against Phytopathogenic Fungi.Candida tropicalis antifungal cross-resistance is related to different azole target (Erg11p) modifications.Screening and Characterization of a Non-cyp51A Mutation in an Aspergillus fumigatus cox10 Strain Conferring Azole Resistance.Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors Biotechnology of non-Saccharomyces yeasts--the ascomycetes.Assessment of selection and resistance risk for demethylation inhibitor fungicides in Aspergillus fumigatus in agriculture and medicine: a critical review.The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back.Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus.Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review.Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51.The Utilization of RNA Silencing Technology to Mitigate the Voriconazole Resistance of Aspergillus Flavus; Lipofectamine-Based Delivery.Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.Multilocus resistance evolution to azole fungicides in fungal plant pathogen populations.Structural insights into impact of Y134F mutation and discovery of novel fungicidal compounds against CYP51 in Puccinia triticina.Theoretical Reactivity Study of Indol-4-Ones and Their Correlation with Antifungal Activity.Sensitivity of Fusarium culmorum to triazoles: impact of trichothecene chemotypes, oxidative stress response and genetic diversity.The binding mechanism between azoles and FgCYP51B, sterol 14α-demethylase of Fusarium graminearum.Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies.Potential drug targets in the Mycobacterium tuberculosis cytochrome P450 system.Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus.Genome-wide analysis of cytochrome P450s of Trichoderma spp.: annotation and evolutionary relationships.

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P2860

Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.

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2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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Fungal cytochrome P450 sterol ...... in plant and human pathogens.

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Fungal cytochrome P450 sterol ...... in plant and human pathogens.

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Rayko Becher

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Stefan G R Wirsel

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P2860

Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola

Structural basis of human CYP51 inhibition by antifungal azoles

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes

Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

Changes in susceptibility to posaconazole in clinical isolates of Candida albicans

Essential gene identification and drug target prioritization in Aspergillus fumigatus

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