Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis - Wikidata - awgldk - TriplyDB

Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis

Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis

http://www.wikidata.org/entity/Q28486631

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Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin.The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors Atomic structure of Mycobacterium tuberculosis CYP121 to 1.06 A reveals novel features of cytochrome P450 Small-Molecule Scaffolds for CYP51 Inhibitors Identified by High-Throughput Screening and Defined by X-Ray Crystallography Mycobacterium tuberculosis CYP130: CRYSTAL STRUCTURE, BIOPHYSICAL CHARACTERIZATION, AND INTERACTIONS WITH ANTIFUNGAL AZOLE DRUGS X-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14 -Demethylase (CYP51)Biochemical and structural characterization of CYP124: A methyl-branched lipid -hydroxylase from Mycobacterium tuberculosis Structural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1 An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction.Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily Kinetic, spectroscopic and thermodynamic characterization of the Mycobacterium tuberculosis adrenodoxin reductase homologue FprA Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1 Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.Fusarium oxysporum fatty-acid subterminal hydroxylase (CYP505) is a membrane-bound eukaryotic counterpart of Bacillus megaterium cytochrome P450BM3.Sterol 14alpha-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family.The cytochrome P450 complement (CYPome) of Streptomyces coelicolor A3(2).A novel sterol 14alpha-demethylase/ferredoxin fusion protein (MCCYP51FX) from Methylococcus capsulatus represents a new class of the cytochrome P450 superfamily.Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2).Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.Quantitation of lanosterol and its major metabolite FF-MAS in an inhibition assay of CYP51 by azoles with atmospheric pressure photoionization based LC-MS/MS.The Mycobacterium tuberculosis cytochrome P450 system.Spin equilibrium and O₂-binding kinetics of Mycobacterium tuberculosis CYP51 with mutations in the histidine-threonine dyad Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.Structural basis for conservation in the CYP51 family.Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51)Drug strategies targeting CYP51 in neglected tropical diseases Mechanism of binding of prothioconazole to Mycosphaerella graminicola CYP51 differs from that of other azole antifungals Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)In Vitro Biochemical Study of CYP51-Mediated Azole Resistance in Aspergillus fumigatus S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosa The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.

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Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis

http://www.wikidata.org/entity/Q28486631

description

1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

article publié dans les Procee ...... f the United States of America

@fr

artículu científicu espublizáu en 1999

@ast

im August 1999 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 1999/08/03)

@sk

vědecký článek publikovaný v roce 1999

@cs

wetenschappelijk artikel (gepubliceerd op 1999/08/03)

@nl

наукова стаття, опублікована в серпні 1999

@uk

name

Characterization and catalytic ...... rom Mycobacterium tuberculosis

@ast

Characterization and catalytic ...... rom Mycobacterium tuberculosis

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Characterization and catalytic ...... rom Mycobacterium tuberculosis

@nl

type

label

Characterization and catalytic ...... rom Mycobacterium tuberculosis

@ast

Characterization and catalytic ...... rom Mycobacterium tuberculosis

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Characterization and catalytic ...... rom Mycobacterium tuberculosis

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Characterization and catalytic ...... rom Mycobacterium tuberculosis

@ast

Characterization and catalytic ...... rom Mycobacterium tuberculosis

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Characterization and catalytic ...... rom Mycobacterium tuberculosis

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Proceedings of the National Academy of Sciences of the United States of America

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Characterization and catalytic ...... rom Mycobacterium tuberculosis

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A. Bellamine

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A. T. Mangla

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M. R. Waterman

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W. D. Nes

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P2860

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae

Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc

CYP51-like gene of Mycobacterium tuberculosis actually encodes a P450 similar to eukaryotic CYP51

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

Sterol phylogenesis and algal evolution.

Prokaryotic hopanoids and other polyterpenoid sterol surrogates.

Immunopathology of tuberculosis: roles of macrophages and monocytes

Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

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10430874

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Akafuba bulwadde

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