Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
about
Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolismUbiquilin-1 is a molecular chaperone for the amyloid precursor proteinRegulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding proteinConstitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloproteaseMunc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processingSerotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretionP2Y2 nucleotide receptor-mediated responses in brain cells.Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavitiesCellular mechanisms of beta-amyloid production and secretionThe role of cerebral amyloid beta accumulation in common forms of Alzheimer disease.Ascidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis.Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminalsSecretases as therapeutic targets for the treatment of Alzheimer's disease.Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation?Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.Diurnal patterns of soluble amyloid precursor protein metabolites in the human central nervous system.Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner.Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal agingExcessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.Alzheimer's-specific effects of soluble beta-amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.Phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production.The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.Post-transcriptional contribution of a cAMP-dependent pathway to the formation of alpha- and beta/gamma-secretases-derived products of beta APP maturation in human cells expressing wild-type and Swedish mutated beta APP.Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis.Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.Evidence for phosphorylation and oligomeric assembly of presenilin 1.Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.Alzheimer's disease: the lipid connection.Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers.Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.Annular structures as intermediates in fibril formation of Alzheimer Abeta17-42Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.Identification and biology of α-secretase.Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein.The Distinct Role of ADAM17 in APP Proteolysis and Microglial Activation Related to Alzheimer's Disease.Metallothionein-III increases ADAM10 activity in association with furin, PC7, and PKCα during non-amyloidogenic processing.Protein Phosphorylation is a Key Mechanism in Alzheimer's Disease.Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activators.Insulin-like growth factor-1 (IGF-1)-induced processing of amyloid-beta precursor protein (APP) and APP-like protein 2 is mediated by different metalloproteinases.Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.
P2860
Q24297873-708AE3AA-DE76-4CEF-8773-8CCEBA407089Q24634983-4B5CB00B-1995-4443-8D9B-D68C23A8F2D1Q28138703-71C7B081-02A2-4D51-9185-AA6CF4A82F17Q28140038-7BC70CE4-959D-4656-80C1-8A523CB37FD5Q28513155-DC60CCA9-D19B-43F4-8CEE-AE1D471EE72FQ28609364-6AB56D3D-ED27-4982-9725-0716A53F3681Q30156903-3B22E0F0-2E10-4197-A280-D19CFBBFD6C7Q31120675-86A570AD-328A-456E-BFB2-607AD8D466C8Q33740154-D5467161-7D55-47A5-827A-34EE91932CD2Q33768345-2A63E065-C2C7-4E3C-9146-79F5D2912B5BQ33798710-E8F3E0B3-F6F4-464E-8676-827283C2F546Q33800559-B2F13C80-4EAB-4666-B5FF-3EC556D0CCDCQ34284352-B8064F70-9E55-4C58-9589-ADF286D21B24Q34764667-E8BD2B68-279D-4B55-B2A8-D5DF699D2221Q35028555-FFF5C493-E618-4170-BADD-3A39445A8C63Q35124855-E9896CA1-83C7-4526-AFFC-17F6F2B62C06Q35237138-1C7F5ED4-93C0-4D93-B5E5-3C22C7C99D4CQ35701937-7D2D7A90-5317-4A3A-8A9E-529D158FF4E3Q35952432-AE64DE36-7631-4584-A559-C7763D480FF8Q36091651-A694A44F-7DAD-4A82-A4F8-9AA2C7236BBFQ36437712-401EFF6E-B1D9-4513-A275-C5D2B1FABD96Q36437874-FE8E65CB-4293-4D81-A833-8183DA71CAD2Q36438286-C6C6B082-32AC-4FA9-8D4E-67C097EC3120Q36610341-565C4F9B-900E-4C16-B912-D570C1346B6FQ36689365-B4888BB2-FFB3-43C6-8931-95732F6F9E8EQ36765433-B1876709-148E-4A86-BCB2-E7F3BDF06BAEQ36772802-E082EF40-EAB6-4CEC-A8E0-527E5B5622A8Q36994590-29BE9539-F5CD-4E81-92B1-D1D0B9811ACDQ37013734-8BB11FF3-D2BE-40A1-AE83-C710A7B69B1BQ37357625-07CD9022-CCE0-4C88-9A97-2878B1DC26B2Q37426694-11F08C05-7D26-4CE7-9A81-352564C8E01FQ37629098-47928E21-63C9-47AF-860C-66B1ED04A350Q37961730-A4213C8C-BE32-45B5-90B7-C66BCE1BFA03Q38362682-29F9AC2C-A9C2-4671-8FDD-AE48062E9144Q38539526-C66504D3-6172-4CA0-9D27-4C50EB3374F8Q38991860-BF2DD582-8678-4EFF-9692-D72BE88CC30AQ39319453-9320E0CD-5A4B-4D62-80BF-88BC6CC4C3C3Q39784350-64D8128A-E929-4361-8A1E-7687DE8AEFF4Q40074092-1361D063-90CB-4170-BC08-46612805E4EDQ40108106-8FF00F11-2488-4448-BFB4-4B7891EC62B1
P2860
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
@ast
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
@en
type
label
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
@ast
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
@en
prefLabel
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
@ast
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
@en
P2860
P356
P1476
Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.19.9195
P407
P577
1993-10-01T00:00:00Z