Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
about
Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized stateInteraction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseAlzheimer's therapeutics: translation of preclinical science to clinical drug developmentγ-Secretase inhibitors and modulators.The same gamma-secretase accounts for the multiple intramembrane cleavages of APPSpotlight on BACE: the secretases as targets for treatment in Alzheimer diseaseCerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review.beta-Amyloid efflux mediated by p-glycoprotein.CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementiaThe amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Current status on Alzheimer disease molecular genetics: from past, to present, to future.A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activityThe intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.Genetic differences in the serum proteome of horses, donkeys and mules are detectable by protein profiling.The Role of presenilins in gamma-secretase activity.The multiple paradoxes of presenilins.Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's diseaseSecretases as therapeutic targets for the treatment of Alzheimer's disease.Potential novel targets for Alzheimer pharmacotherapy: I. Secretases.Disordered proteins in dementia.Synaptic therapy in Alzheimer's disease: a CREB-centric approach.Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.Changes in the ageing brain in health and disease.The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism.Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (A beta) peptide in the human neuroblastoma cellsEVALUATION OF HOW CIGARETTE SMOKE IS A DIRECT RISK FACTOR FOR ALZHEIMER'S DISEASE.The alpha5beta1 integrin mediates elimination of amyloid-beta peptide and protects against apoptosis.Cerebrospinal fluid tau, A beta, and phosphorylated tau protein for the diagnosis of Alzheimer's disease.Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8 (SAMP8) mice.Evidence for phosphorylation and oligomeric assembly of presenilin 1.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid beta proteinBiochemical studies in Normal Pressure Hydrocephalus (NPH) patients: change in CSF levels of amyloid precursor protein (APP), amyloid-beta (Aβ) peptide and phospho-tauHuman blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain.Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?Toll-like receptors are key players in neurodegeneration.Neurochemical dementia diagnostics in Alzheimer's disease: where are we now and where are we going?γ-Secretase inhibitors and modulators for Alzheimer's disease.
P2860
Q22254058-194F3840-5421-43F9-B49E-265622AF7AF7Q24317439-1615C3E9-CCAE-4D24-B3E4-90452CE32675Q26829267-AAC6D64E-8664-4D97-AE1A-F85E631CABAAQ26830462-8A472134-73F5-4849-BE15-197C3054FF81Q28284426-F8713D02-1DDD-44AE-A6F1-4A8AD62F3B45Q28363447-7600B5B4-0A65-45F4-8F96-59F808B3594CQ31146512-6036113A-BE4A-4207-98C1-F0C54E13051BQ31962046-451F6CD9-590C-4374-962D-39ED599D50E9Q33239180-9996CF47-A922-471F-A551-0A44E8F7BE5CQ33601404-9BCD9535-4E6A-4D93-9545-0E84C8C1048FQ33871345-48CD09B0-AA15-4A0D-AA16-5C8A90C6C5E7Q33991052-0CACCAE0-68DE-48D4-9AC7-DD9C4AF6C29CQ34009371-C6BC6D58-9E25-4400-A545-82D623CFDA5FQ34049888-89A77D08-669E-4FA7-8CCD-6358674B3099Q34116345-6FF91B18-7A2A-438B-AEBB-A23F67440853Q34190161-DB9E10AB-3092-4F33-8396-3DD58E93A6D6Q34221138-6DA29FFC-2759-4E5F-B047-6B8F0599FA9DQ34284352-CFD069EC-F0ED-4CD3-B360-1CF402094598Q34703558-79A3E52C-BAC5-4E85-B509-0C9CEFBF3C47Q34952164-AAD2DB99-2F2F-4325-9AD0-1937FAA97D77Q35064948-8D08CD41-00E5-4081-A849-9640450C351CQ35065215-31D458F5-9CD7-496A-8FCD-89FE040BA8F5Q35211845-C4C2F0EB-3F5A-40B4-A8FF-CB4CFF291BB8Q35578655-93867E85-F980-4469-A661-9EC491BAD0E6Q36047013-8B2DF938-546F-49F7-8885-478986535C9DQ36241900-7D9ED336-E798-47F2-A942-36A0BD72CC8EQ36255383-4801BB70-D9B3-4C23-A044-903B3DB28E86Q36382217-52571F70-755B-468D-818A-FC9B7D300AA9Q36459592-96F32FEF-9C27-4656-810A-79535355B43EQ36683174-6E9BEB91-D7F0-45DD-BF18-10AEEE9D76FBQ36765433-66BCBD7C-110E-4044-969A-76D7E12440A8Q37108151-168426FC-9D28-4672-8BC6-109A68591773Q37240159-96E9A96E-547A-4671-87C0-F985E43FB505Q37269006-A221F57A-0C3B-4AB6-BCB5-042559103B62Q37384492-12ADC35F-9516-4BB9-80E7-95E7A18B6D27Q37394529-FFD1A2CB-D580-4A89-9533-83C560A820BAQ37609644-9DCB5739-6C0D-472F-9763-C1099F69B78DQ37880364-51A04EA3-6DF2-415B-9EE4-8FA5FB60522FQ37912199-6752FF34-3385-4411-A5A0-F9ED79156EDBQ37961792-6CF74B25-3FEA-42B5-B59C-CFBF6A555C6A
P2860
Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Evidence that the 42- and 40-a ...... different protease activities.
@ast
Evidence that the 42- and 40-a ...... different protease activities.
@en
type
label
Evidence that the 42- and 40-a ...... different protease activities.
@ast
Evidence that the 42- and 40-a ...... different protease activities.
@en
prefLabel
Evidence that the 42- and 40-a ...... different protease activities.
@ast
Evidence that the 42- and 40-a ...... different protease activities.
@en
P2093
P2860
P356
P1476
Evidence that the 42- and 40-a ...... different protease activities.
@en
P2093
P2860
P304
13170-13175
P356
10.1073/PNAS.93.23.13170
P407
P577
1996-11-01T00:00:00Z