Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.
about
The Alzheimer's amyloid-degrading peptidase, neprilysin: can we control it?Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's diseaseThe Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds CholesterolCo-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.Association of differential gene expression with imatinib mesylate and omacetaxine mepesuccinate toxicity in lymphoblastoid cell lines.Potential role of Notch signalling in CD34+ chronic myeloid leukaemia cells: cross-talk between Notch and BCR-ABLThe role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch.Polyhydroxycurcuminoids but not curcumin upregulate neprilysin and can be applied to the prevention of Alzheimer's disease.Mechanisms of Amyloid-β Peptide Clearance: Potential Therapeutic Targets for Alzheimer's Disease.Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer's DiseaseOriginal Research: Featured Article: Imatinib mesylate (Gleevec) inhibits Notch and c-Myc signaling: Five-day treatment permanently rescues mammary development.Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?The physiology of the β-amyloid precursor protein intracellular domain AICD.The amyloid precursor protein: a biochemical enigma in brain development, function and disease.Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes.Do Cancer Drugs Counteract Neurodegeneration? Repurposing for Alzheimer's Disease.Surfaceome profiling reveals regulators of neural stem cell function.Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease.Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism.ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease.Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms.The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain.
P2860
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P2860
Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
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2007年学术文章
@zh-cn
2007年学术文章
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2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
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2007年學術文章
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2007年學術文章
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name
Gleevec increases levels of th ...... a degrading enzyme neprilysin.
@en
type
label
Gleevec increases levels of th ...... a degrading enzyme neprilysin.
@en
prefLabel
Gleevec increases levels of th ...... a degrading enzyme neprilysin.
@en
P2093
P2860
P356
P1476
Gleevec increases levels of th ...... a degrading enzyme neprilysin.
@en
P2093
Bert Klebl
Christina Nordhammer
Ellen Kilger
Matthias Baumann
Yvonne S Eisele
P2860
P304
P356
10.1091/MBC.E07-01-0035
P577
2007-07-11T00:00:00Z