Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
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MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strainsFurther evidence for the association of CYP2D6*4 gene polymorphism with Parkinson's disease: a case control studyMetabolite profile resulting from the activation/inactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 2-methyltetrahydro-β-carboline by oxidative enzymes.Studies on metabolites and metabolic pathways of bulleyaconitine A in rat liver microsomes using LC-MS(n) combined with specific inhibitors.Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications.Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP+ by Transporter-Independent Export of the Intermediate MPDP+.The Effect of MSCs Derived from the Human Umbilical Cord Transduced by Fibroblast Growth Factor-20 on Parkinson's Disease.Unusual cytochrome p450 enzymes and reactions.Chemopreventative effects of tetrahydrocurcumin on human diseases.Pharmacogenetics of tardive dyskinesia: an updated review of the literature.Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs.Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan.Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice.Neuroprotective effects of the gliopeptide ODN in an in vivo model of Parkinson's disease.Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas.Effects of partial inhibition of respiratory complex I on H2O 2 production by isolated brain mitochondria in different respiratory states.Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson's models.
P2860
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P2860
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Metabolism of 1-methyl-4-pheny ...... ications in Parkinson disease.
@ast
Metabolism of 1-methyl-4-pheny ...... ications in Parkinson disease.
@en
type
label
Metabolism of 1-methyl-4-pheny ...... ications in Parkinson disease.
@ast
Metabolism of 1-methyl-4-pheny ...... ications in Parkinson disease.
@en
prefLabel
Metabolism of 1-methyl-4-pheny ...... ications in Parkinson disease.
@ast
Metabolism of 1-methyl-4-pheny ...... ications in Parkinson disease.
@en
P2093
P2860
P356
P1476
Metabolism of 1-methyl-4-pheny ...... ications in Parkinson disease.
@en
P2093
F Peter Guengerich
Goutam Chowdhury
Ji-Kang Fang
Martha V Martin
Michelle C Sangar
Narayan G Avadhani
Prachi Bajpai
Qian Cheng
Seema Bansal
Shilpee Singh
P2860
P304
P356
10.1074/JBC.M112.402123
P407
P577
2012-12-20T00:00:00Z