A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives.
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Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function propertiesRadicals: Reactive Intermediates with Translational PotentialDe novo production of the plant-derived alkaloid strictosidine in yeastTotal synthesis of (-)-kopsinine and ent-(+)-kopsinineTotal Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications.Total synthesis of kopsinine.Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates.Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface.Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.Structural elaboration of a natural product: identification of 3,3'-diindolylmethane aminophosphonate and urea derivatives as potent anticancer agents.Theoretical insight into the structural mechanism for the binding of vinblastine with tubulin.Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs.Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent.Improving monoterpene geraniol production through geranyl diphosphate synthesis regulation in Saccharomyces cerevisiae.Furan-Site Bromination and Transformations of Fraxinellone as Insecticidal Agents Against Mythimna separata Walker.Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums† †Electronic supplementary information (ESI) available: Experimental procedures and characterisation data for all compounds are provided. CCDC 1Cobalt bis(acetylacetonate)--butyl hydroperoxide-triethylsilane: a general reagent combination for the Markovnikov-selective hydrofunctionalization of alkenes by hydrogen atom transfer
P2860
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P2860
A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A remarkable series of vinblas ...... erance: C20' urea derivatives.
@ast
A remarkable series of vinblas ...... erance: C20' urea derivatives.
@en
type
label
A remarkable series of vinblas ...... erance: C20' urea derivatives.
@ast
A remarkable series of vinblas ...... erance: C20' urea derivatives.
@en
prefLabel
A remarkable series of vinblas ...... erance: C20' urea derivatives.
@ast
A remarkable series of vinblas ...... erance: C20' urea derivatives.
@en
P2093
P2860
P356
P1476
A remarkable series of vinblas ...... erance: C20' urea derivatives.
@en
P2093
Dale L Boger
Erick K Leggans
Katharine K Duncan
Kristin D Schleicher
Timothy J Barker
P2860
P304
P356
10.1021/JM3015684
P407
P577
2012-12-17T00:00:00Z