A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
about
Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleusIron in chronic brain disorders: imaging and neurotherapeutic implications.Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells.Fluorescence lifetime measurements and biological imagingThe role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells.A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding siteHistologic validation of locus coeruleus MRI contrast in post-mortem tissue.Direct intranigral injection of dopaminochrome causes degeneration of dopamine neuronsHuman neuromelanin: an endogenous microglial activator for dopaminergic neuron deathDeath in the substantia nigra: a motor tragedy.Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic interventionRole and mechanism of microglial activation in iron-induced selective and progressive dopaminergic neurodegeneration.Complexity of dopamine metabolism.Evidence for the ectopic synthesis of melanin in human adipose tissue.Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle.The multiple faces of quercetin in neuroprotection.Phenotypic profile of alternative activation marker CD163 is different in Alzheimer's and Parkinson's disease.Iron in neuronal function and dysfunction.Neuropathology of sporadic Parkinson disease before the appearance of parkinsonism: preclinical Parkinson disease.The pleiotropic roles of autophagy regulators in melanogenesis.Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?Limbic system pathologies associated with deficiencies and excesses of the trace elements iron, zinc, copper, and selenium.Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism.Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator.Cytotoxicity of dopaminochrome in the mesencephalic cell line, MN9D, is dependent upon oxidative stressSubstrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase.Long-term course of substantia nigra hyperechogenicity in Parkinson's disease.Activation of the proopiomelanocortin gene with ketoconazole as a treatment for Parkinson's disease: a new hypothesis.The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease.Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: a cross-sectional study.Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits.Parkinson's disease related signal change in the nigrosomes 1-5 and the substantia nigra using T2* weighted 7T MRI.
P2860
Q28831116-4CED13A5-A27A-4C2B-95AB-415F792147D9Q31117154-B490CD06-C2B1-4A64-8ADA-9862A447E0A1Q33389875-6E714A9B-C660-4538-90D5-AF8765099D8EQ34076309-69124C27-F79D-4FEC-AA4F-13D24E16BD8BQ34428287-C0B926F6-1988-49A7-91C3-936AB72FE086Q34658144-8FC0E8C5-0BF9-463F-9BA2-4CE6E01A488EQ35673412-AF41D098-236C-45D6-ABF3-957EF0D48ED6Q36292320-BCB9FC0B-7811-40E0-A060-36CE7477B7EFQ36505602-07E5416C-46F9-452B-8D10-EF45616D58BFQ36766407-4FC76321-8D9A-40A5-8DAE-8D8D9DD5AF42Q36847262-230F33FA-5FE2-49BF-8DF8-22113E6B865AQ36919403-61A2BB6E-5823-4405-B451-ACBC9899B2F3Q36931995-D830B2AA-950E-449F-A0EB-D8AD4097BFB1Q36958208-3A7025C2-16CD-4FB8-94F9-B380B4763A92Q37123950-769AF73C-B7FF-4038-AE3D-F9FEA359B260Q37509229-D3C0BFA8-A77F-4974-829D-A0E4A1E56DC7Q37524001-86973FBE-2292-4F2A-8AB7-5EDCD71C2495Q37612968-B53080CA-813E-4443-889B-4FD6E6255C3DQ37709937-6D8500C9-C8F0-492C-9F63-5A1CA44E7265Q37791469-908EBEF5-E4EF-434F-8962-20A1D9F9A428Q37903418-A10BFBFE-8381-490C-AD53-1C52F1236664Q38014888-5616D1A1-D42C-4792-9E95-C071E0AF37D8Q38064534-BA4FA2E9-B2D6-4CB8-B29F-C627D9E17960Q38920210-CF76E61E-B698-4498-9394-7FC2D7EF5886Q39282039-22DE7B3C-596A-4640-85F7-92CF3B3F8770Q39823008-0E887348-F30F-42E8-8A88-976DCB911BA9Q40615919-E203898D-E3BD-4955-83FC-8EBD7C123625Q45953462-17A41A14-34F8-48A2-B165-597F72015F9AQ46201322-364127EC-8B0F-41D5-8765-157E4A7CF039Q46663033-665817E3-CA99-401C-9800-BBE3320EF2EEQ47855821-A1241749-C5F2-41C1-B55D-CCD6E16016ABQ48101192-DA880EE2-C57F-4C35-B0EA-17F25B5C5474Q55312441-E88E6CFD-F0F8-4521-9416-ED5F40267AD0
P2860
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
@ast
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
@en
type
label
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
@ast
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
@en
prefLabel
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
@ast
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
@en
P2093
P1433
P1476
A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease.
@en
P2093
P356
10.1212/WNL.67.7_SUPPL_2.S8
P407
P433
P577
2006-10-01T00:00:00Z