Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
about
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington diseaseHuntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neuronspARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingMutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's diseaseIntracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseasesPossible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's diseaseHuntingtin's function in axonal transport is conserved in Drosophila melanogasterThe insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinHuntingtin mediates dendritic transport of β-actin mRNA in rat neuronsLoss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiationSerine 421 regulates mutant huntingtin toxicity and clearance in mice.Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in miceSynaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms.Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease.Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network BiologyFull-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expressionHuntington disease models and human neuropathology: similarities and differencesDirected PCR-free engineering of highly repetitive DNA sequences.Transgenic rat model of Huntington's disease: a histopathological study and correlations with neurodegenerative process in the brain of HD patients.BDNF signaling and survival of striatal neurons.Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane.Dysfunctional mitochondrial respiration in the striatum of the Huntington's disease transgenic R6/2 mouse model.HD CAG-correlated gene expression changes support a simple dominant gain of function.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.Huntington's Disease and Striatal Signaling.Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.Mass spectrometric identification of novel lysine acetylation sites in huntingtinMutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's diseaseMitochondria as a therapeutic target for aging and neurodegenerative diseases.Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.The emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseThe role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention.Co-clustering phenome-genome for phenotype classification and disease gene discovery.Mitotic spindle (DIS)orientation and DISease: cause or consequence?Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease
P2860
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P2860
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
@ast
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
@en
type
label
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
@ast
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
@en
prefLabel
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
@ast
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.
@en
P2093
P50
P1476
Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies
@en
P2093
M Borrell-Pagès
P2888
P304
P356
10.1007/S00018-006-6242-0
P577
2006-11-01T00:00:00Z