Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.
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Update on rational targeted therapy in AMLRegulation of Bim in Health and DiseaseAdvances in targeting signal transduction pathwaysPI3K and cancer: lessons, challenges and opportunitiesMCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.Rational combination of dual PI3K/mTOR blockade and Bcl-2/-xL inhibition in AML.Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.Toll-like receptor 4-mediated signaling participates in apoptosis of hippocampal neurons.PI3K/mTOR inhibition markedly potentiates HDAC inhibitor activity in NHL cells through BIM- and MCL-1-dependent mechanisms in vitro and in vivo.CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis.Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines.PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.Rational Combinations of Targeted Agents in AMLRapamycin rescues ABT-737 efficacy in small cell lung cancerCombined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo.Depletion of the chromatin remodeler CHD4 sensitizes AML blasts to genotoxic agents and reduces tumor formationCyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimeticsSynergistic anti-tumor activity and inhibition of angiogenesis by cotargeting of oncogenic and death receptor pathways in human melanomaPhosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients.Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation.Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia.4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells.mTOR pathway in colorectal cancer: an update.Targeting prohibitins induces apoptosis in acute myeloid leukemia cells.That which does not kill me makes me stronger; combining ERK1/2 pathway inhibitors and BH3 mimetics to kill tumour cells and prevent acquired resistance.The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches.Targeting novel signaling pathways for resistant acute myeloid leukemia.Outlook on PI3K/AKT/mTOR inhibition in acute leukemia.Rational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies.Targeting mTOR for the treatment of B cell malignancies.Therapeutically targeting SELF-reinforcing leukemic niches in acute myeloid leukemia: A worthy endeavor?Epothilone B induces apoptosis and enhances apoptotic effects of ABT-737 on human cancer cells via PI3K/AKT/mTOR pathway.Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells.5,7-Dihydroxy-4'-methoxyisoflavone induces apoptosis by inhibiting the ERK and Akt pathways in human osteosarcoma cells.Caspase-dependent Mcl-1 cleavage and effect of Mcl-1 phosphorylation in ABT-737-induced apoptosis in human acute lymphoblastic leukemia cell lines.Metastatic SW620 colon cancer cells are primed for death when detached and can be sensitized to anoikis by the BH3-mimetic ABT-737.PI3K inhibitor GDC-0941 enhances apoptotic effects of BH-3 mimetic ABT-737 in AML cells in the hypoxic bone marrow microenvironment.
P2860
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P2860
Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Dual inhibition of Bcl-2 and B ...... - and Bim-dependent mechanism.
@ast
Dual inhibition of Bcl-2 and B ...... - and Bim-dependent mechanism.
@en
type
label
Dual inhibition of Bcl-2 and B ...... - and Bim-dependent mechanism.
@ast
Dual inhibition of Bcl-2 and B ...... - and Bim-dependent mechanism.
@en
prefLabel
Dual inhibition of Bcl-2 and B ...... - and Bim-dependent mechanism.
@ast
Dual inhibition of Bcl-2 and B ...... - and Bim-dependent mechanism.
@en
P2093
P2860
P1433
P1476
Dual inhibition of Bcl-2 and B ...... 3- and Bim-dependent mechanism
@en
P2093
Andrea Ferreira-Gonzalez
David C Williams
Elisa Attkisson
Mandy Mayo Aust
Steven Grant
P2860
P304
P356
10.1158/0008-5472.CAN-12-1365
P407
P577
2012-12-12T00:00:00Z