Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.
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Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathwaysHerpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic stepHerpes simplex virus type 1 immediate-early protein ICP27 is required for efficient incorporation of ICP0 and ICP4 into virionsMta has properties of an RNA export protein and increases cytoplasmic accumulation of Epstein-Barr virus replication gene mRNA.Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export.Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathwaysHerpes simplex virus ICP27 induces cytoplasmic accumulation of unspliced polyadenylated alpha-globin pre-mRNA in infected HeLa cells.Processing of alpha-globin and ICP0 mRNA in cells infected with herpes simplex virus type 1 ICP27 mutants.The conserved carboxyl-terminal half of herpes simplex virus type 1 regulatory protein ICP27 is dispensable for viral growth in the presence of compensatory mutationsAccumulation of herpes simplex virus type 1 early and leaky-late proteins correlates with apoptosis prevention in infected human HEp-2 cells.Herpes simplex virus ICP27 activation of stress kinases JNK and p38.Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.Herpes simplex virus type 1 infection leads to loss of serine-2 phosphorylation on the carboxyl-terminal domain of RNA polymerase II.UL54-null pseudorabies virus is attenuated in mice but productively infects cells in cultureDirect stimulation of translation by the multifunctional herpesvirus ICP27 protein.Nuclear export of VP19C is not essential for replication of herpes simplex virus type 1Mapping of functional regions in the amino-terminal portion of the herpes simplex virus ICP27 regulatory protein: importance of the leucine-rich nuclear export signal and RGG Box RNA-binding domain.ICP27 interacts with the C-terminal domain of RNA polymerase II and facilitates its recruitment to herpes simplex virus 1 transcription sites, where it undergoes proteasomal degradation during infection.Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 geneMultiple roles of Epstein-Barr virus SM protein in lytic replication.Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27.Regulatory function of the equine herpesvirus 1 ICP27 gene product.Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expressionHerpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA.Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genesThe RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation.The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer.Herpes simplex virus type 1 ICP27 regulates expression of a variant, secreted form of glycoprotein C by an intron retention mechanism.Efficient nuclear export of herpes simplex virus 1 transcripts requires both RNA binding by ICP27 and ICP27 interaction with TAP/NXF1Role of immediate early protein ICP27 in the differential sensitivity of herpes simplex viruses 1 and 2 to leptomycin BHerpesvirus protein ICP27 switches PML isoform by altering mRNA splicing.Functional comparison of herpes simplex virus 1 (HSV-1) and HSV-2 ICP27 homologs reveals a role for ICP27 in virion release.Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylationThe Epstein-Barr virus SM protein is functionally similar to ICP27 from herpes simplex virus in viral infectionsNucleocytoplasmic shuttling of human cytomegalovirus UL84 is essential for virus growth.CK2 protein kinase is stimulated and redistributed by functional herpes simplex virus ICP27 proteinPhysical and functional interactions between herpes simplex virus immediate-early proteins ICP4 and ICP27.Transactivation of a viral target gene by herpes simplex virus ICP27 is posttranscriptional and does not require the endogenous promoter or polyadenylation site.
P2860
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P2860
Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Amino acid substitution mutati ...... tial gene regulation function.
@ast
Amino acid substitution mutati ...... tial gene regulation function.
@en
type
label
Amino acid substitution mutati ...... tial gene regulation function.
@ast
Amino acid substitution mutati ...... tial gene regulation function.
@en
prefLabel
Amino acid substitution mutati ...... tial gene regulation function.
@ast
Amino acid substitution mutati ...... tial gene regulation function.
@en
P2860
P1433
P1476
Amino acid substitution mutati ...... ntial gene regulation function
@en
P2860
P304
P407
P577
1994-02-01T00:00:00Z