Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. - Wikidata - awgldk - TriplyDB

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

http://www.wikidata.org/entity/Q36638686

about

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms The critical role of Akt in cardiovascular function Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors.Molecular markers of paragangliomas/pheochromocytomas MYC Deregulation in Primary Human Cancers.Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.Regulation of the human catalytic subunit of telomerase (hTERT).Genetic markers associated with early cancer-specific mortality following prostatectomy Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation The enhanced in vivo activity of the combination of a MEK and a PI3K inhibitor correlates with [18F]-FLT PET in human colorectal cancer xenograft tumour-bearing mice.Distinct Transcriptomic Features are Associated with Transitional and Mature B-Cell Populations in the Mouse Spleen.Troglitazone suppresses c-Myc levels in human prostate cancer cells via a PPARγ-independent mechanism PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis An animal model of MYC-driven medulloblastoma MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy The transposon-driven evolutionary origin and basis of histone deacetylase functions and limitations in disease prevention.Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1).Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis.B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells.Amplitude modulation of androgen signaling by c-MYC.Regulation of the kinase RSK1 by arsenic trioxide and generation of antileukemic responses Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells.Degradation of Akt using protein-catalyzed capture agents.C-C Motif Chemokine Receptor 9 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK.Myc's broad reach.TCP10L synergizes with MAD1 in transcriptional suppression and cell cycle arrest through mutual interaction.An overview of MYC and its interactome.Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells.The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription.

P2860

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P2860

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

http://www.wikidata.org/entity/Q36638686

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Activation of PI3K/Akt and MAP ...... oting the degradation of Mad1.

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Activation of PI3K/Akt and MAP ...... oting the degradation of Mad1.

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type

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Activation of PI3K/Akt and MAP ...... oting the degradation of Mad1.

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Activation of PI3K/Akt and MAP ...... oting the degradation of Mad1.

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prefLabel

Activation of PI3K/Akt and MAP ...... oting the degradation of Mad1.

@ast

Activation of PI3K/Akt and MAP ...... oting the degradation of Mad1.

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Activation of PI3K/Akt and MAP ...... oting the degradation of Mad1.

@en

P2093

Jidong Zhu

http://www.w3.org/2001/XMLSchema#string

John Blenis

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Junying Yuan

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P2860

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity

Expression, regulation, and chromosomal localization of the Max gene

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Synthesis and function of 3-phosphorylated inositol lipids

Expression of Mad1 in T cells leads to reduced thymic cellularity and impaired mitogen-induced proliferation

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

Function of the c-Myc oncogenic transcription factor.

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.

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6584-6589

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10.1073/PNAS.0802785105

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105

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18451027

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phosphorylation

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2373325

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