An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.
about
Transcriptional dysregulation in Huntington's disease: a failure of adaptive transcriptional homeostasisThe N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic miceA method to rapidly create protein aggregates in living cells.Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR ApproachGeneration and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.Free-Energy Landscape of the Amino-Terminal Fragment of Huntingtin in Aqueous SolutionUnmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation.Probing the Huntingtin 1-17 membrane anchor on a phospholipid bilayer by using all-atom simulationsPolyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopyIntegration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.The emerging role of the first 17 amino acids of huntingtin in Huntington's diseaseHuntingtin N-Terminal Monomeric and Multimeric Structures Destabilized by Covalent Modification of Heteroatomic Residues.Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapySUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.Pharmacological protein targets in polyglutamine diseases: mutant polypeptides and their interactors.Polyglutamine expansion affects huntingtin conformation in multiple Huntington's disease models.Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.Atomistic mechanisms of huntingtin N-terminal fragment insertion on a phospholipid bilayer revealed by molecular dynamics simulations.Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases.Searching for Correlations Between the Development of Neurodegenerative Hallmarks: Targeting Huntingtin as a Contributing Factor.Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity.Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
P2860
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P2860
An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
An N-terminal nuclear export s ...... ntingtin (Htt) protein exon 1.
@ast
An N-terminal nuclear export s ...... ntingtin (Htt) protein exon 1.
@en
type
label
An N-terminal nuclear export s ...... ntingtin (Htt) protein exon 1.
@ast
An N-terminal nuclear export s ...... ntingtin (Htt) protein exon 1.
@en
prefLabel
An N-terminal nuclear export s ...... ntingtin (Htt) protein exon 1.
@ast
An N-terminal nuclear export s ...... ntingtin (Htt) protein exon 1.
@en
P2093
P2860
P356
P1476
An N-terminal nuclear export s ...... untingtin (Htt) protein exon 1
@en
P2093
Jayne C Marasa
Marc I Diamond
Zhiqiang Zheng
P2860
P304
P356
10.1074/JBC.M112.413575
P407
P577
2013-01-14T00:00:00Z