ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation - Wikidata - awgldk - TriplyDB

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

http://www.wikidata.org/entity/Q36647913

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RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1 Mdm2 induces mono-ubiquitination of FOXO4 Nodal enhances the activity of FoxO3a and its synergistic interaction with Smads to regulate cyclin G2 transcription in ovarian cancer cells Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation A new fork for clinical application: targeting forkhead transcription factors in cancer Regulation of Bim in Health and Disease Redox regulation of FoxO transcription factors Pathobiology of Paget's Disease of Bone Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer FOXO transcription factors: key regulators of cellular quality control FOXO transcription factors throughout T cell biology PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms Signaling cross-talk in the resistance to HER family receptor targeted therapy Mitochondria and FOXO3: breath or die Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim TFEB links autophagy to lysosomal biogenesis Adenosine monophosphate activated protein kinase (AMPK), a mediator of estradiol-induced apoptosis in long-term estrogen deprived breast cancer cells.Bimodal regulation of FoxO3 by AKT and 14-3-3 Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target p38α MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine.FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation.Modelling the response of FOXO transcription factors to multiple post-translational modifications made by ageing-related signalling pathways G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein?Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?Adjustment for smoking does not alter the FOXO3A association with longevity.From basic research to clinical development of MEK1/2 inhibitors for cancer therapy.High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.The Erk2 MAPK regulates CD8 T cell proliferation and survival.FOXD3 is a mutant B-RAF-regulated inhibitor of G(1)-S progression in melanoma cells.Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma beta1-Integrin-collagen interaction suppresses FoxO3a by the coordination of Akt and PP2A Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7

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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

http://www.wikidata.org/entity/Q36647913

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

@zh-mo

2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

@ast

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

@en

type

label

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

@ast

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

@en

prefLabel

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

@ast

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

@en

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Nature Cell Biology

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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

@en

P2093

Aysegul A Sahin

http://www.w3.org/2001/XMLSchema#string

Chang-Hai Tsai

http://www.w3.org/2001/XMLSchema#string

Chien-Chen Lai

http://www.w3.org/2001/XMLSchema#string

Chun-Ju Chang

http://www.w3.org/2001/XMLSchema#string

Chwan-Deng Hsiao

http://www.w3.org/2001/XMLSchema#string

Cong S Zong

http://www.w3.org/2001/XMLSchema#string

Dihua Yu

http://www.w3.org/2001/XMLSchema#string

Dung-Fang Lee

http://www.w3.org/2001/XMLSchema#string

Fuu-Jen Tsai

http://www.w3.org/2001/XMLSchema#string

Gabriel N Hortobagyi

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

The Hallmarks of Cancer

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

Cancer genes and the pathways they control

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

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138-148

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scholarly article

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10.1038/NCB1676

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2

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10

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2008-01-20T00:00:00Z

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5648049

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1029052135

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18204439

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2376808

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