Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.
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Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in DrosophilaParkin mono-ubiquitinates Bcl-2 and regulates autophagySCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibitionThe ubiquitin proteasome system in neuropathologyCargos and genes: insights into vesicular transport from inherited human diseaseThe pathogenesis of Niemann-Pick type C disease: a role for autophagy?Protein homeostasis and aging: taking care of proteins from the cradle to the graveWhy should autophagic flux be assessed?Photoreceptor cell death and rescue in retinal detachment and degenerationsDeveloping therapeutic approaches to tau, selected kinases, and related neuronal protein targetsAutophagy in the Pathogenesis of DiseaseParkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Halofuginone Synergistically Enhances Anti-Proliferation of Rapamycin in T Cells and Reduces Cytotoxicity of Cyclosporine in Cultured Renal Tubular Epithelial CellsOverexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph diseaseRapamycin induces pluripotent genes associated with avoidance of replicative senescenceSex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in miceRevisiting and revising the purinosomeRole of autophagy in cancerHepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin.Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy.Progranulin modulates zebrafish motoneuron development in vivo and rescues truncation defects associated with knockdown of Survival motor neuron 1.Proteasome failure promotes positioning of lysosomes around the aggresome via local block of microtubule-dependent transport.Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathyLoss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbancesA scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.Small molecule regulators of autophagy identified by an image-based high-throughput screen.Role of the ubiquitin proteasome system in Parkinson's disease.Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesSelective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathyDecreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragmentTransgenic Drosophila models of Alzheimer's disease and tauopathiesTau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors.Autophagic induction of amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cellsBim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis.The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis.The C/EBPbeta isoform, liver-inhibitory protein (LIP), induces autophagy in breast cancer cell lines.Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagyHow the nucleus copes with proteotoxic stress.Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection.SOD2, the principal scavenger of mitochondrial superoxide, is dispensable for embryogenesis and imaginal tissue development but essential for adult survival
P2860
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P2860
Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Aggregate-prone proteins are c ...... agy: therapeutic implications.
@ast
Aggregate-prone proteins are c ...... agy: therapeutic implications.
@en
type
label
Aggregate-prone proteins are c ...... agy: therapeutic implications.
@ast
Aggregate-prone proteins are c ...... agy: therapeutic implications.
@en
prefLabel
Aggregate-prone proteins are c ...... agy: therapeutic implications.
@ast
Aggregate-prone proteins are c ...... agy: therapeutic implications.
@en
P2093
P1476
Aggregate-prone proteins are c ...... agy: therapeutic implications.
@en
P2093
Andrea Williams
Brinda Ravikumar
David C Rubinsztein
Fiona M Menzies
Luca Jahreiss
Shinji Saiki
Sovan Sarkar
P304
P356
10.1016/S0070-2153(06)76003-3
P577
2006-01-01T00:00:00Z