Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism.
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Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginineCrystal structure of human annexin I at 2.5 A resolutionStructural Characterization of Myotoxic Ecarpholin S From Echis carinatus VenomInterfacial catalysis: the mechanism of phospholipase A2Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogueThe calcium binding sites in human annexin V by crystal structure analysis at 2.0 A resolution. Implications for membrane binding and calcium channel activityPhospholipase A2 biochemistryCrystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution.Phospholipase A2: its usefulness in laboratory diagnostics.Structural effects of covalent inhibition of phospholipase A2 suggest allosteric coupling between membrane binding and catalytic sites.Activation of mitochondrial calcium-independent phospholipase A2γ (iPLA2γ) by divalent cations mediating arachidonate release and production of downstream eicosanoids.Atomic resolution (0.97 A) structure of the triple mutant (K53,56,121M) of bovine pancreatic phospholipase A2.A requirement for membrane-associated phospholipase A2 in platelet cytotoxicity activated by receptors for immunoglobulin G and complement.Evidence that a 16-kilodalton integral membrane protein antigen from Schistosoma japonicum adult worms is a type A2 phospholipase.Critical role of a hydrogen bond in the interaction of phospholipase A2 with transition-state and substrate analoguesActive-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis.Structural determinants of the hyperalgesic activity of myotoxic Lys49-phospholipase A2.The interaction of phospholipase A2 with a phospholipid bilayer: coarse-grained molecular dynamics simulations.Cytosolic phospholipase A2 from human monocytic cells: characterization of substrate specificity and Ca(2+)-dependent membrane associationThe binding of amide substrate analogues to phospholipase A2. Studies by 13C-nuclear-magnetic-resonance and infrared spectroscopy.Sequence-induced trimerization of phospholipase A2: structure of a trimeric isoform of PLA2 from common krait (Bungarus caeruleus) at 2.5 A resolution.The pKa of the catalytic histidine residue of chloramphenicol acetyltransferase.Inhibition of Neurotoxic Secretory Phospholipases A(2) Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth.Topology of the substrate-binding site of a Lys49-phospholipase A2 influences Ca2+-independent membrane-damaging activity.Tailoring the pH dependence of human non-pancreatic secretory phospholipase A2 by engineering surface charges.Mechanism of inhibition of human nonpancreatic secreted phospholipase A2 by the anti-inflammatory agent BMS-181162.The intrinsic tryptophan fluorescence of beta 1-bungarotoxin and the Ca2+-binding domains of the toxin as probed with Tb3+ luminescence.A novel phospholipase A2 from human placenta.Improved pKa calculations through flexibility based sampling of a water-dominated interaction scheme.A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change.Fluorometric assays of phospholipase A2 activity with three different substrates in biological samples of patients with schizophrenia.Phospholipases A2 from Callosellasma rhodostoma venom gland cloning and sequencing of 10 of the cDNAs, three-dimensional modelling and chemical modification of the major isozyme.Purification and partial characterization of an anticoagulant PLA2 from the venom of Indian Daboia russelii that induces inflammation through upregulation of proinflammatory mediators.N-methyl-D-aspartate-sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells.Dimerization regulates the enzymatic activity of Escherichia coli outer membrane phospholipase A.
P2860
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P2860
Methylation of histidine-48 in pancreatic phospholipase A2. Role of histidine and calcium ion in the catalytic mechanism.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年論文
@yue
1980年論文
@zh-hant
1980年論文
@zh-hk
1980年論文
@zh-mo
1980年論文
@zh-tw
1980年论文
@wuu
1980年论文
@zh
1980年论文
@zh-cn
name
Methylation of histidine-48 in ...... on in the catalytic mechanism.
@ast
Methylation of histidine-48 in ...... on in the catalytic mechanism.
@en
type
label
Methylation of histidine-48 in ...... on in the catalytic mechanism.
@ast
Methylation of histidine-48 in ...... on in the catalytic mechanism.
@en
prefLabel
Methylation of histidine-48 in ...... on in the catalytic mechanism.
@ast
Methylation of histidine-48 in ...... on in the catalytic mechanism.
@en
P2093
P356
P1433
P1476
Methylation of histidine-48 in ...... on in the catalytic mechanism.
@en
P2093
B W Dijkstra
E H Jansen
G H de Haas
H M Verheij
J J Volwerk
P304
P356
10.1021/BI00545A021
P407
P577
1980-02-01T00:00:00Z