Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.
about
Detailed analysis of gene expression during development of T cell lineages in the thymus.Interaction between the mouse homologue of CD99 and its ligand PILR as a mechanism of T cell receptor-independent thymocyte apoptosis.Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival.The majority of postselection CD4+ single-positive thymocytes requires the thymus to produce long-lived, functional T cells.T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytesRequirement for p56lck tyrosine kinase activation in T cell receptor-mediated thymic selectionThymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chainsA novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells.Direct detection of FoxP3 expression in thymic double-negative CD4-CD8- cells by flow cytometry.Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands.Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway.The function of the CD4 coreceptor in the development of T cells.NMR-Directed Design of PreTCRβ and pMHC Molecules Implies a Distinct Geometry for preTCR Relative to αβTCR Recognition of pMHC.Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.Chimeric protein of CD8a extracellular domain and CD4 transmembrane and cytoplasmic domain binds more efficiently to p56lck than CD8a
P2860
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P2860
Thymocyte development in major histocompatibility complex-deficient mice: evidence for stochastic commitment to the CD4 and CD8 lineages.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Thymocyte development in major ...... t to the CD4 and CD8 lineages.
@ast
Thymocyte development in major ...... t to the CD4 and CD8 lineages.
@en
type
label
Thymocyte development in major ...... t to the CD4 and CD8 lineages.
@ast
Thymocyte development in major ...... t to the CD4 and CD8 lineages.
@en
prefLabel
Thymocyte development in major ...... t to the CD4 and CD8 lineages.
@ast
Thymocyte development in major ...... t to the CD4 and CD8 lineages.
@en
P2093
P2860
P356
P1476
Thymocyte development in major ...... t to the CD4 and CD8 lineages.
@en
P2093
L H Glimcher
M J Grusby
P2860
P304
10739-10743
P356
10.1073/PNAS.90.22.10739
P407
P577
1993-11-01T00:00:00Z