Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes
about
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiationThemis, a T cell-specific protein important for late thymocyte developmentDevelopment of all CD4 T lineages requires nuclear factor TOXITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytesTranscriptional control of CD4 and CD8 coreceptor expression during T cell developmentReview article: thymus organ cultures and T-cell receptor repertoire development.Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice.Depletion and recovery of lymphoid subsets following morphine administration.Thymic low affinity/avidity interaction selects natural Th1 cellsTwo distinct pathways of positive selection for thymocytes.HD mice: a novel mouse mutant with a specific defect in the generation of CD4(+) T cells.CD4-CD8 lineage commitment: an inside view.The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.Positive and negative selection invoke distinct signaling pathways.Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.Unraveling a revealing paradox: Why major histocompatibility complex I-signaled thymocytes "paradoxically" appear as CD4+8lo transitional cells during positive selection of CD8+ T cellsLck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitionsLineage commitment in the thymus: only the most differentiated (TCRhibcl-2hi) subset of CD4+CD8+ thymocytes has selectively terminated CD4 or CD8 synthesis.Commitment of immature CD4+8+ thymocytes to the CD4 lineage requires CD3 signaling but does not require expression of clonotypic T cell receptor (TCR) chainsRole of the transcription factor Th-POK in CD4:CD8 lineage commitment.Commitment issues: linking positive selection signals and lineage diversification in the thymus.Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentationDynamic repositioning of CD4 and CD8 genes during T cell development.Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice.Visualization of CD4/CD8 T cell commitment.Beta-catenin regulates positive selection of thymocytes but not lineage commitment.Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexesSignaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.Gads-deficient thymocytes are blocked at the transitional single positive CD4+ stage.The impact of negative selection on thymocyte migration in the medulla.CD4/CD8 lineage commitment: back to instruction?A potential role for Elf-1 in CD4 promoter function.ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage.Asynchronous coreceptor downregulation after positive thymic selection: prolonged maintenance of the double positive state in CD8 lineage differentiation due to sustained biosynthesis of the CD4 coreceptor.Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.How Thymocytes Achieve Their Fate.Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate.Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment.A molecular chart of thymocyte positive selection.An influence of CD5 on the selection of CD4-lineage T cells.
P2860
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P2860
Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Intermediate steps in positive ...... es into CD4-8+TCRhi thymocytes
@ast
Intermediate steps in positive ...... es into CD4-8+TCRhi thymocytes
@en
type
label
Intermediate steps in positive ...... es into CD4-8+TCRhi thymocytes
@ast
Intermediate steps in positive ...... es into CD4-8+TCRhi thymocytes
@en
prefLabel
Intermediate steps in positive ...... es into CD4-8+TCRhi thymocytes
@ast
Intermediate steps in positive ...... es into CD4-8+TCRhi thymocytes
@en
P2093
P2860
P356
P1476
Intermediate steps in positive ...... es into CD4-8+TCRhi thymocytes
@en
P2093
P2860
P304
P356
10.1084/JEM.181.5.1643
P407
P577
1995-05-01T00:00:00Z