Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
about
Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensingPhosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.Targeting of AMP-activated protein kinase: prospects for computer-aided drug design.Structural and biochemical insights into the allosteric activation mechanism of AMP-activated protein kinase.Structure and Regulation of AMPK.AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.Inhibition of MAPK pathway is essential for suppressing Rheb-Y35N driven tumor growth.AMPK in skeletal muscle function and metabolism.AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.2-[2-(4-(trifluoromethyl)phenylamino)thiazol-4-yl]acetic acid (Activator-3) is a potent activator of AMPK.
P2860
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P2860
Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Structural basis of allosteric ...... sphonic derivative C2 binding.
@ast
Structural basis of allosteric ...... sphonic derivative C2 binding.
@en
type
label
Structural basis of allosteric ...... sphonic derivative C2 binding.
@ast
Structural basis of allosteric ...... sphonic derivative C2 binding.
@en
prefLabel
Structural basis of allosteric ...... sphonic derivative C2 binding.
@ast
Structural basis of allosteric ...... sphonic derivative C2 binding.
@en
P2093
P2860
P50
P356
P1476
Structural basis of allosteric ...... sphonic derivative C2 binding.
@en
P2093
Kevin R W Ngoei
Michael A Gorman
Naomi X Y Ling
Sam M A Issa
P2860
P2888
P356
10.1038/NCOMMS10912
P407
P50
P577
2016-03-08T00:00:00Z