The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function.
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Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathwaysHerpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic stepHerpes simplex virus type 1 immediate-early protein ICP27 is required for efficient incorporation of ICP0 and ICP4 into virionsMta has properties of an RNA export protein and increases cytoplasmic accumulation of Epstein-Barr virus replication gene mRNA.Hsc70 focus formation at the periphery of HSV-1 transcription sites requires ICP27.Analysis of the phosphorylation sites of herpes simplex virus type 1 regulatory protein ICP27.ICP27 recruits Aly/REF but not TAP/NXF1 to herpes simplex virus type 1 transcription sites although TAP/NXF1 is required for ICP27 export.The Epstein-Barr virus (EBV) SM protein enhances pre-mRNA processing of the EBV DNA polymerase transcript.Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathwaysProcessing of alpha-globin and ICP0 mRNA in cells infected with herpes simplex virus type 1 ICP27 mutants.The conserved carboxyl-terminal half of herpes simplex virus type 1 regulatory protein ICP27 is dispensable for viral growth in the presence of compensatory mutationsIdentification of an export control sequence and a requirement for the KH domains in ICP27 from herpes simplex virus type 1Accumulation of herpes simplex virus type 1 early and leaky-late proteins correlates with apoptosis prevention in infected human HEp-2 cells.Herpes simplex virus ICP27 activation of stress kinases JNK and p38.Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein.Mapping of functional regions in the amino-terminal portion of the herpes simplex virus ICP27 regulatory protein: importance of the leucine-rich nuclear export signal and RGG Box RNA-binding domain.ICP27 interacts with the C-terminal domain of RNA polymerase II and facilitates its recruitment to herpes simplex virus 1 transcription sites, where it undergoes proteasomal degradation during infection.ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cellsRegulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5.Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 geneIdentification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27.Regulatory function of the equine herpesvirus 1 ICP27 gene product.Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expressionHerpes simplex virus trans-regulatory protein ICP27 stabilizes and binds to 3' ends of labile mRNA.Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genesThe RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation.The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection.Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function.Cooperativity among herpes simplex virus type 1 immediate-early regulatory proteins: ICP4 and ICP27 affect the intracellular localization of ICP0Role of immediate early protein ICP27 in the differential sensitivity of herpes simplex viruses 1 and 2 to leptomycin BArginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replication.Functional comparison of herpes simplex virus 1 (HSV-1) and HSV-2 ICP27 homologs reveals a role for ICP27 in virion release.Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.Global analysis of herpes simplex virus type 1 transcription using an oligonucleotide-based DNA microarray.The immediate-early gene product encoded by open reading frame 57 of herpesvirus saimiri modulates gene expression at a posttranscriptional level.The open reading frame (ORF) 50a gene product regulates ORF 57 gene expression in herpesvirus saimiri.The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylationThe Epstein-Barr virus SM protein is functionally similar to ICP27 from herpes simplex virus in viral infectionsCK2 protein kinase is stimulated and redistributed by functional herpes simplex virus ICP27 proteinRegulation of herpes simplex virus poly (A) site usage and the action of immediate-early protein IE63 in the early-late switch.
P2860
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P2860
The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
The acidic amino-terminal regi ...... r an essential lytic function.
@ast
The acidic amino-terminal regi ...... r an essential lytic function.
@en
type
label
The acidic amino-terminal regi ...... r an essential lytic function.
@ast
The acidic amino-terminal regi ...... r an essential lytic function.
@en
prefLabel
The acidic amino-terminal regi ...... r an essential lytic function.
@ast
The acidic amino-terminal regi ...... r an essential lytic function.
@en
P2093
P2860
P1433
P1476
The acidic amino-terminal regi ...... or an essential lytic function
@en
P2093
P2860
P304
P407
P577
1993-04-01T00:00:00Z