The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein.
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Crystal structure of the retinoblastoma tumor suppressor protein bound to E2F and the molecular basis of its regulationAccumulation of human papillomavirus type 16 E7 protein bypasses G1 arrest induced by serum deprivation and by the cell cycle inhibitor p21The canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein.The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sitesAnchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16.Destabilization of the retinoblastoma tumor suppressor by human papillomavirus type 16 E7 is not sufficient to overcome cell cycle arrest in human keratinocytes.Potent anti-tumor effect generated by a novel human papillomavirus (HPV) antagonist peptide reactivating the pRb/E2F pathway.Biology of human papillomaviruses.Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins.Inactivation of both the retinoblastoma tumor suppressor and p21 by the human papillomavirus type 16 E7 oncoprotein is necessary to inhibit cell cycle arrest in human epithelial cells.The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.Clefts, grooves, and (small) pockets: the structure of the retinoblastoma tumor suppressor in complex with its cellular target E2F unveiled.Inhibition of HPV-16 E6/E7 immortalization of normal keratinocytes by hairpin ribozymes.Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoproteinHuman papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressorFunctional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2Comparison of the properties of the E6 and E7 genes of low- and high-risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1.Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex.Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.Human papillomavirus type 16 E7 oncoprotein associates with E2F6.Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk virusesThe papillomavirus E7 proteins.The human papillomavirus E7 oncoprotein.Manipulation of cellular DNA damage repair machinery facilitates propagation of human papillomaviruses.HPV16 E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes.Identification of distinct roles for separate E1A domains in disruption of E2F complexes.Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7.Complementary functions of E1a conserved region 1 cooperate with conserved region 3 to activate adenovirus serotype 5 early promoters.Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes.A Mathematical Model of Cell Cycle Dysregulation Due to Human Papillomavirus Infection.Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes.Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model.
P2860
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P2860
The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein.
description
1993 nî lūn-bûn
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1993年の論文
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1993年論文
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1993年論文
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1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
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1993年论文
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1993年论文
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name
The human papillomavirus E7 on ...... toma tumor suppressor protein.
@ast
The human papillomavirus E7 on ...... toma tumor suppressor protein.
@en
type
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The human papillomavirus E7 on ...... toma tumor suppressor protein.
@ast
The human papillomavirus E7 on ...... toma tumor suppressor protein.
@en
prefLabel
The human papillomavirus E7 on ...... toma tumor suppressor protein.
@ast
The human papillomavirus E7 on ...... toma tumor suppressor protein.
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P2093
P2860
P1433
P1476
The human papillomavirus E7 on ...... stoma tumor suppressor protein
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P2093
P2860
P304
P407
P577
1993-04-01T00:00:00Z