Dimer formation by an N-terminal coiled coil in the APC protein.
about
EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologueThe tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phaseAttenuated APC alleles produce functional protein from internal translation initiation.APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.Genotype-phenotype correlations in attenuated adenomatous polyposis coli.Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc geneA targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumorsExamination of actin and microtubule dependent APC localisations in living mammalian cells.The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1)Molecular Basis for the Recognition of Adenomatous Polyposis Coli by the Discs Large 1 ProteinTesting models of the APC tumor suppressor/β-catenin interaction reshapes our view of the destruction complex in Wnt signalingApc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and developmentNuclear APCHuman homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site.Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families.Immunopurification of adenomatous polyposis coli (APC) proteins.A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancersAdenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1.Apc(MIN) modulation of vitamin D secosteroid growth controlARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.Two hits revisited againForce generation by cytoskeletal filament end-tracking proteinsWhat we could do now: molecular pathology of colorectal cancer.MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase.Self-association of the APC tumor suppressor is required for the assembly, stability, and activity of the Wnt signaling destruction complex.Biology of colorectal cancer.A critical role for the regulated wnt-myc pathway in naive T cell survivalCortical localization of APC2 plays a role in actin organization but not in Wnt signaling in DrosophilaAn unusually severe phenotype for familial adenomatous polyposisDestruction complex function in the Wnt signaling pathway of Drosophila requires multiple interactions between Adenomatous polyposis coli 2 and ArmadilloHereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC geneNuclear and cytoplasmic localizations of the adenomatous polyposis coli protein.Absence of somatic alterations of the EB1 gene adenomatous polyposis coli-associated protein in human sporadic colorectal cancersPredicting oligomerization states of coiled coilsChromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APCAPC gene mutations and colorectal adenomatosis in familial adenomatous polyposis.Analysis of masked mutations in familial adenomatous polyposisDifferent APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis.Genetic prognostic markers in colorectal cancerForced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium.
P2860
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P2860
Dimer formation by an N-terminal coiled coil in the APC protein.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Dimer formation by an N-terminal coiled coil in the APC protein.
@ast
Dimer formation by an N-terminal coiled coil in the APC protein.
@en
type
label
Dimer formation by an N-terminal coiled coil in the APC protein.
@ast
Dimer formation by an N-terminal coiled coil in the APC protein.
@en
prefLabel
Dimer formation by an N-terminal coiled coil in the APC protein.
@ast
Dimer formation by an N-terminal coiled coil in the APC protein.
@en
P2093
P2860
P356
P1476
Dimer formation by an N-terminal coiled coil in the APC protein.
@en
P2093
P2860
P304
11109-11113
P356
10.1073/PNAS.90.23.11109
P407
P577
1993-12-01T00:00:00Z