Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2
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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acidsProtective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2Glc7/protein phosphatase 1 regulatory subunits can oppose the Ipl1/aurora protein kinase by redistributing Glc7.Vps factors are required for efficient transcription elongation in budding yeast.TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectorsThe mutant type 1 protein phosphatase encoded by glc7-1 from Saccharomyces cerevisiae fails to interact productively with the GAC1-encoded regulatory subunitThe type 1 phosphatase Reg1p-Glc7p is required for the glucose-induced degradation of fructose-1,6-bisphosphatase in the vacuole.The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growthDisrupting vesicular trafficking at the endosome attenuates transcriptional activation by Gcn4.Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M.GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2.Regulation of chromosome segregation by Glc8p, a structural homolog of mammalian inhibitor 2 that functions as both an activator and an inhibitor of yeast protein phosphatase 1Homologous segments in three subunits of the guanine nucleotide exchange factor eIF2B mediate translational regulation by phosphorylation of eIF2.Convergence of the target of rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element)-regulated genes.Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae.Molecular characterization of Ypi1, a novel Saccharomyces cerevisiae type 1 protein phosphatase inhibitor.The Saccharomyces SHP1 gene, which encodes a regulator of phosphoprotein phosphatase 1 with differential effects on glycogen metabolism, meiotic differentiation, and mitotic cell cycle progression.Molecular characterization of GCV3, the Saccharomyces cerevisiae gene coding for the glycine cleavage system hydrogen carrier protein.The molecular biology of multidomain proteins. Selected examplesFeedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaTranscriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeastRegulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase.Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeastSnf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.Inhibition of translation initiation by volatile anesthetics involves nutrient-sensitive GCN-independent and -dependent processes in yeast.Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase.The yeast translational allosuppressor, SAL6: a new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension.Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution.The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms.Glucose signaling in Saccharomyces cerevisiae.Glucose depletion rapidly inhibits translation initiation in yeastThe Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast.An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α.Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.The EGP1 gene may be a positive regulator of protein phosphatase type 1 in the growth control of Saccharomyces cerevisiae.Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes.
P2860
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P2860
Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Truncated protein phosphatase ...... or the eIF-2 alpha kinase GCN2
@ast
Truncated protein phosphatase ...... or the eIF-2 alpha kinase GCN2
@en
type
label
Truncated protein phosphatase ...... or the eIF-2 alpha kinase GCN2
@ast
Truncated protein phosphatase ...... or the eIF-2 alpha kinase GCN2
@en
prefLabel
Truncated protein phosphatase ...... or the eIF-2 alpha kinase GCN2
@ast
Truncated protein phosphatase ...... or the eIF-2 alpha kinase GCN2
@en
P2093
P2860
P356
P1476
Truncated protein phosphatase ...... or the eIF-2 alpha kinase GCN2
@en
P2093
P2860
P304
P356
10.1128/MCB.12.12.5700
P407
P577
1992-12-01T00:00:00Z