Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
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Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila BehaviorsTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Drosophila as an In Vivo Model for Human Neurodegenerative DiseaseThe C9orf72 repeat expansion disrupts nucleocytoplasmic transport.Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLDAxonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.Role of BMP receptor traffic in synaptic growth defects in an ALS model.Motor neuron expression of the voltage-gated calcium channel cacophony restores locomotion defects in a Drosophila, TDP-43 loss of function model of ALS.Neural Circuits Underlying Fly Larval LocomotionDrosophila lines with mutant and wild type human TDP-43 replacing the endogenous gene reveals phosphorylation and ubiquitination in mutant lines in the absence of viability or lifespan defects.Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration.Deletion of C9ORF72 results in motor neuron degeneration and stress sensitivity in C. elegansA fruitful endeavor: modeling ALS in the fruit flyInduction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.PABPN1 suppresses TDP-43 toxicity in ALS disease models.TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.Disease animal models of TDP-43 proteinopathy and their pre-clinical applications.Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration.Amyotrophic lateral sclerosis: Problems and prospects.Loss and gain of FUS function impair neuromuscular synaptic transmission in a genetic model of ALS.The Role of TDP-43 in Alzheimer's Disease.Restoration of motor defects caused by loss of Drosophila TDP-43 by expression of the voltage-gated calcium channel, Cacophony, in central neurons.Frontotemporal Lobar Degeneration: Mechanisms and Therapeutic Strategies.Prevalence of TDP-43 proteinopathy in cognitively normal older adults: systematic review and meta-analysis.TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.Simple animal models for amyotrophic lateral sclerosis drug discovery.Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2.Axonal transport defects are a common phenotype in Drosophila models of ALS.Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP.Psychomotor Behavior: A Practical Approach in DrosophilaReduced TDP-43 Expression Improves Neuronal Activities in a Drosophila Model of Perry Syndrome.Failure to Deliver and Translate-New Insights into RNA Dysregulation in ALS.Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2.Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster.Exploring the Interaction of Drosophila TDP-43 and the Type II Voltage-Gated Calcium Channel, Cacophony, in Regulating Motor Function and Behavior.Mitochondrial abnormalities and disruption of the neuromuscular junction precede the clinical phenotype and motor neuron loss in hFUSWT transgenic mice.Downregulation of glutamic acid decarboxylase in Drosophila TDP-43-null brains provokes paralysis by affecting the organization of the neuromuscular synapses.Secreted tissue inhibitor of matrix metalloproteinase restricts trans-synaptic signaling to coordinate synaptogenesis.A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.RNA buffers the phase separation behavior of prion-like RNA binding proteins.
P2860
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P2860
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Loss and gain of Drosophila TD ...... by loss-of-function phenotypes
@ast
Loss and gain of Drosophila TD ...... by loss-of-function phenotypes
@en
type
label
Loss and gain of Drosophila TD ...... by loss-of-function phenotypes
@ast
Loss and gain of Drosophila TD ...... by loss-of-function phenotypes
@en
prefLabel
Loss and gain of Drosophila TD ...... by loss-of-function phenotypes
@ast
Loss and gain of Drosophila TD ...... by loss-of-function phenotypes
@en
P2093
P2860
P50
P356
P1476
Loss and gain of Drosophila TD ...... by loss-of-function phenotypes
@en
P2093
Alan Stepto
Bart Dermaut
Christopher J H Elliott
Dickon M Humphrey
Iain M Robinson
Lies Vanden Broeck
Patrick Callaerts
Yoshitsugu Adachi
P2860
P304
P356
10.1093/HMG/DDT005
P577
2013-01-10T00:00:00Z