Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model
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Cryptococcus and Phagocytes: Complex Interactions that Influence Disease OutcomeInsights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosisClinical characteristics of disseminated cryptococcosis in previously healthy children in China.Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis.TLR9 signaling is required for generation of the adaptive immune protection in Cryptococcus neoformans-infected lungs.Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lungSTAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice.Immune modulation mediated by cryptococcal laccase promotes pulmonary growth and brain dissemination of virulent Cryptococcus neoformans in mice.Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection.Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans.Outbred ICR/CD1 mice display more severe neuroinflammation mediated by microglial TLR4/CD14 activation than inbred C57Bl/6 miceCryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans.Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarizationIL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms.STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformansThe Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunityVirulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.Susceptibility to progressive Cryptococcus neoformans pulmonary infection is regulated by loci on mouse chromosomes 1 and 9.Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection.Cryptococcus neoformans growth and protection from innate immunity are dependent on expression of a virulence-associated DEAD-box protein, Vad1.Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformansMacrophage M1/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection.Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung.Cryptococcus: from environmental saprophyte to global pathogen.Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus neoformans.Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection.Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon productionMechanisms of cryptococcal virulence and persistence.Induction of protective immunity against cryptococcosis.Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections.Local GM-CSF-Dependent Differentiation and Activation of Pulmonary Dendritic Cells and Macrophages Protect against Progressive Cryptococcal Lung Infection in Mice.Role of dendritic cell-pathogen interactions in the immune response to pulmonary cryptococcal infection.T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection.The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses.Innate Immune Responses to Cryptococcus.Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infectionEnhanced innate immune responsiveness to pulmonary Cryptococcus neoformans infection is associated with resistance to progressive infection.
P2860
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P2860
Inheritance of immune polarization patterns is linked to resistance versus susceptibility to Cryptococcus neoformans in a mouse model
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Inheritance of immune polariza ...... us neoformans in a mouse model
@ast
Inheritance of immune polariza ...... us neoformans in a mouse model
@en
type
label
Inheritance of immune polariza ...... us neoformans in a mouse model
@ast
Inheritance of immune polariza ...... us neoformans in a mouse model
@en
prefLabel
Inheritance of immune polariza ...... us neoformans in a mouse model
@ast
Inheritance of immune polariza ...... us neoformans in a mouse model
@en
P2093
P2860
P356
P1476
Inheritance of immune polariza ...... us neoformans in a mouse model
@en
P2093
David A McNamara
Galen B Toews
Gary B Huffnagle
Gwo-hsiao Chen
Yadira Hernandez
P2860
P304
P356
10.1128/IAI.01143-07
P407
P577
2008-04-07T00:00:00Z