Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit. - Wikidata - awgldk - TriplyDB

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.

http://www.wikidata.org/entity/Q36714253

about

Alterations in Mitochondrial Quality Control in Alzheimer's Disease Mitochondria: A Therapeutic Target for Parkinson's Disease?Mitochondrial dynamism and heart disease: changing shape and shaping change Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase.Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease.Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression.Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity.Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons.Mitochondrial genome linearization is a causative factor for cardiomyopathy in mice and Drosophila.Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish.The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble.Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction.VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease.Mitochondrial fusion proteins and human diseases.Mitochondria dynamism: of shape, transport and cell migration.Disturbed mitochondrial dynamics and neurodegenerative disorders.How mitochondrial dynamism orchestrates mitophagy.Dissecting the role of Engrailed in adult dopaminergic neurons--Insights into Parkinson disease pathogenesis Mitochondrial fusion, fission, and mitochondrial toxicity.Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes.A conserved retromer sorting motif is essential for mitochondrial DLP1 recycling by VPS35 in Parkinson's disease model.In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells.Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death.Mitochondrial fission and fusion in secondary brain damage after CNS insults.Histone decacetylase inhibitors prevent mitochondrial fragmentation and elicit early neuroprotection against MPP+.Selective mitochondrial depletion, apoptosis resistance, and increased mitophagy in human Charcot-Marie-Tooth 2A motor neurons.Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.Mitochondrial division inhibitor-1 is neuroprotective in the A53T-α-synuclein rat model of Parkinson's disease.

P2860

Q26768215-55772483-7068-436C-BA01-181572BD1C07 Q26784216-A7D907F0-B8CA-4797-9218-698AAC11701C Q26825299-A2D931CA-2339-4BC4-AE36-622CABA1AE9A Q27001001-2488B564-C0E9-41FA-86CD-C06643C88E5B Q27318046-8CEAA2CF-9F81-4A82-B025-A0E3683C4D16 Q28588501-61CC9D47-C4CB-4A2B-BDDF-03269C2DC40A Q30444939-5FA65A59-2D36-48D2-80BF-F61E73FAD191 Q30577415-BA32BDD5-5E35-476E-865C-8310804618BF Q33585950-06CFA241-5683-4324-8878-7B8B9010F451 Q33649447-B9A10359-6DE5-49E6-9C23-CE1F4654CEA3 Q34080716-56C4F54E-0E72-4AE1-B272-FA0BDACBAE61 Q34383447-8A0C9A74-0421-4406-BCD4-AF205EFD3181 Q34399661-3550FC0F-9D9B-4B2F-83B2-BB67B48AA0C0 Q34470315-E01B05B5-D3EC-4B77-B382-86E684586F88 Q34806938-6A54B79C-B648-4E86-A219-662F6AC917DB Q34807191-5DD2E6D2-A363-4493-A08B-C3C96F815E3B Q35094282-97BFBF3A-4E8D-4499-8B8E-4F1338E2FCE5 Q35662291-72580137-6636-4D82-B60E-03A1864B905A Q35708874-C58898A1-EA1B-4BEB-A50D-59459772A1DE Q36048102-55CD4448-3910-4FD0-ADC1-9F291DFA3F2C Q36372732-F16FABE9-94B2-4966-B8F0-F44CBB210F42 Q37336130-100AEDC6-64BA-46A9-A951-D377B0C300E6 Q37339111-FF62455D-EE87-474B-A730-528AD101B0A4 Q37509682-A5426251-7BF9-4834-BAF4-C84C78F4A9C7 Q38115530-30AC31D6-16A5-4E64-9C58-A4FE36914AD0 Q38179990-DAD98F3B-83A5-4483-97F0-9A1C8F3CFA1E Q38285228-4788F788-19B8-4607-ABB9-09E731C5326A Q38497008-241420A1-17C4-443E-97E4-0A50ECB15F74 Q38605280-AB282186-E734-4443-9626-8C4EB3443471 Q38645270-5BC560FA-ACCB-4DCE-876E-2C239322DE58 Q38702403-BA76F287-6DE2-4E0E-9E0C-C698747301B5 Q38723392-890C8E62-819B-447A-B6A7-CC4F32BAC5E7 Q38753758-87DA69BB-AEFF-4E6C-BEB0-A16C2E4B4DD5 Q38943638-B5BBC894-E015-4387-A971-62E0D0D0B89D Q38963722-CC643422-4536-4CAE-98A9-EA6D29E1B814 Q38966173-E68A3DFB-BCA6-454F-BE98-FF9A7789CA42 Q39042148-9BD6DAC7-8169-4E45-92C5-204857CBE91A Q39506552-E0855C86-ABB7-4CF4-B44B-A6209B9ABE81 Q40231021-D20BEAEE-26BC-4197-9A26-79D70D1CCBC2 Q41308603-4BAF674A-2237-44B5-B309-B2A3344AC259

P2860

Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit.

http://www.wikidata.org/entity/Q36714253

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Loss of Mfn2 results in progre ...... in the nigrostriatal circuit.

@ast

Loss of Mfn2 results in progre ...... in the nigrostriatal circuit.

@en

type

label

Loss of Mfn2 results in progre ...... in the nigrostriatal circuit.

@ast

Loss of Mfn2 results in progre ...... in the nigrostriatal circuit.

@en

prefLabel

Loss of Mfn2 results in progre ...... in the nigrostriatal circuit.

@ast

Loss of Mfn2 results in progre ...... in the nigrostriatal circuit.

@en

P1433

Q36714253-5EF132B5-68B2-43ED-A4B1-F3A1B46827F4

P1476

Q36714253-54FDBC66-C384-4022-8A00-27F6652B8D07

P2093

Q36714253-8774A72F-766A-431C-991B-9C97726E7B23

Q36714253-C4EA989A-FDA0-4921-9218-B5887909C39F

Q36714253-DD7EF025-ED03-4969-86A7-989213AA21C9

Q36714253-F2BEA2ED-FDDB-4AE7-8314-A6B454E17067

P2860

Q36714253-05711980-FBCC-473B-B47B-8D12A5876855

Q36714253-0D4D2D6E-EEA8-48FC-B1CB-F88F0CEE8884

Q36714253-1130FB7D-57DB-4FAF-BF9E-C753E4EE4207

Q36714253-14E92340-FE27-4E0B-B2E8-8713C438059C

Q36714253-16205BF5-9734-42CD-842A-52DFC1A55F7E

Q36714253-1BB04F4F-64BF-4146-A069-14A71616C0D0

Q36714253-1BD77600-69CA-4812-AB39-38FF1F3536A5

Q36714253-1CA636B6-D62C-45C7-9BD3-01E4D43ACB82

Q36714253-206C0DBF-4CAE-47FC-8AA0-D6FF2033D099

Q36714253-23BC780A-9A5B-4097-8FAD-0D2ADDADA239

P304

Q36714253-72FC77EF-EBC9-4DCF-AB11-3CD9EF44845C

P31

Q36714253-3E48B40E-2FD3-4A63-A4D1-C71437E45B62

P356

Q36714253-5A92718F-65DA-454E-A559-6CECBFC2C70E

P433

Q36714253-6EEA3CB7-9973-4BC2-80AC-4ADF99BC35DD

P478

Q36714253-543F1F7E-16F5-4202-BA60-E674B4790D3A

P577

Q36714253-195772A3-5D4B-4748-962A-2250BC16731E

P5875

Q36714253-879AD723-E0A2-4A34-9A2B-73D1B897BB0D

P698

Q36714253-19113A21-FF29-43C8-A25B-9A95FD1A7835

P921

Q36714253-DDB0F1C1-A544-4DDB-96EA-802D08C2621B

P932

Q36714253-343109C5-1B8C-47B6-9921-CC6873C71918

P356

P1433

Human Molecular Genetics

P1476

Loss of Mfn2 results in progre ...... in the nigrostriatal circuit.

@en

P2093

Anh H Pham

http://www.w3.org/2001/XMLSchema#string

David C Chan

http://www.w3.org/2001/XMLSchema#string

Quynh N Chu

http://www.w3.org/2001/XMLSchema#string

Shuxia Meng

http://www.w3.org/2001/XMLSchema#string

P2860

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration.

Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

The PINK1/Parkin pathway regulates mitochondrial morphology

P304

4817-4826

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1093/HMG/DDS311

http://www.w3.org/2001/XMLSchema#string

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

21

http://www.w3.org/2001/XMLSchema#string

P577

2012-07-31T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230629493

http://www.w3.org/2001/XMLSchema#string

P698

22859504

http://www.w3.org/2001/XMLSchema#string

P921

P932

3607482

http://www.w3.org/2001/XMLSchema#string